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Author response: Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent
Authors
Author Affiliations
Research Institute for Tropical Medicine, Ollscoil na Gaillimhe – University of Galway, Wellcome Sanger Institute, B.P. Koirala Institute of Health Sciences, ...
Year2016
Citations4
Abstract
Full text Figures and data Side by side Abstract eLife digest Introduction Results Discussion Materials and methods Appendix 1 - SNP detection procedure using the COCALL algorithm Appendix 2 - Somy, CNV, indel and episome detection Data availability References Decision letter Author response Article and author information Metrics Abstract Leishmania donovani causes visceral leishmaniasis (VL), the second most deadly vector-borne parasitic disease. A recent epidemic in the Indian subcontinent (ISC) caused up to 80% of global VL and over 30,000 deaths per year. Resistance against antimonial drugs has probably been a contributing factor in the persistence of this epidemic. Here we use whole genome sequences from 204 clinical isolates to track the evolution and epidemiology of L. donovani from the…
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