Journal ArticleOpen Access
Clinical and epidemiological features of the 2014 large-scale dengue outbreak in Guangzhou city, China
Authors
Author Affiliations
Guangzhou Medical University, First Affiliated Hospital of Guangzhou Medical University, Guangzhou University of Chinese Medicine, University of Hong Kong, ...
Published InBMC Infectious Diseases
Year2016
Citations40
Abstract
BACKGROUND: Dengue virus is transmitted by mosquito around the tropical and sub-tropical regions. There was a large-scale dengue epidemic in Guangdong province, China during 2014 and around fifty thousands dengue fever cases, including six deaths, have been reported. In this study, we aimed to understand the clinical characteristics of hospitalized patients with laboratory-confirmed dengue virus (DENV) infection and determined the origin of the virus from the outbreak. METHODS: We have summarized the data from 138 hospitalized patients who were laboratory confirmed for dengue infection in Guangzhou city. Patients were classified as either non-severe dengue fever or severe dengue fever according to the guidelines from the WHO. Viral serotypes were determined by real time RT-PCR. Genetic sequences of the envelope and…
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