ReviewOpen Access
Circulating tumor DNA in cancer diagnosis, monitoring, and prognosis
Authors
Author Affiliations
Independent University, Shahjalal University of Science and Technology
Published InJournal of the Egyptian National Cancer Institute
Year2022
Citations43
Abstract
BACKGROUND: Circulating tumor DNA (ctDNA) has become one of the crucial components for cancer detection with the increase of precision medicine practice. ctDNA has great potential as a blood-based biomarker for the detection and treatment of cancer in its early stages. The purpose of this article was to discuss ctDNA and how it can be utilized to detect cancer. The benefits and drawbacks of this cancer detection technology, as well as the field's future possibilities in various cancer management scenarios, are discussed. MAIN TEXT: ctDNA has clinical applications in disease diagnosis and monitoring. It can be used to identify mutations of interest and genetic heterogeneity. Another use of ctDNA is to monitor the effects of therapy by detecting mutation-driven resistance.…
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