Journal ArticleOpen Access
Epidemiology, clinical characteristics, and genetic diversity of Nipah virus strains from Bangladesh: 2016-2023
Author Affiliations
International Centre for Diarrhoeal Disease Research, International Commission for the Protection of the Danube River, Institute of Epidemiology, Disease Control and Research, Centers for Disease Control and Prevention, ...
Published InInternational Journal of Infectious Diseases
Year2025
Citations5
Abstract
OBJECTIVES: Nipah virus (NiV) causes deadly outbreaks in Bangladesh, with a fatality rate of 71%. Two sublineages, NiV-BD 1 and NiV-BD 2, have been identified. This study aimed to characterize their epidemiologic and clinical diversity. METHODS: This study analyzed 21 new (2016-2023) and 17 previously (2012-2015) reported NiV genome sequences and compared sublineages using descriptive and bivariate analysis. RESULTS: The median age of sequenced cases was 17 years (Interquartile Range (IQR): 9-30), 66% were male. Raw date palm sap consumption was main transmission pathway (92%). NiV-BD 2 showed a broader geographic distribution, including the southern region. The sublineages did not differ significantly in age, sex, or transmission modes. Both sublineages presented with fever, altered mental status, and unconsciousness. Respiratory distress…
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