Ensemble of Convolutional Neural Networks to diagnose Acute Lymphoblastic Leukemia from microscopic images

Acute Lymphoblastic Leukemia (ALL) is a blood cell cancer characterized by the presence of excess immature lymphocytes., Even though automation in ALL prognosis is essential for cancer diagnosis, it remains a challenge due to the morphological correlation between malignant and normal cells. The traditional ALL classification strategy demands that experienced pathologists read cell images carefully, which is arduous, time-consuming, and often hampered by interobserver variation. This article has automated the ALL recognition task by employing deep Convolutional Neural Networks (CNNs). The weighted ensemble of deep CNNs is explored to recommend a better ALL cell classifier. The weights are estimated from ensemble candidates’ corresponding metrics, such as F1-score, area under the curve (AUC), and kappa values. Various data augmentations and pre-processing…