P-586. 2025 Nipah Outbreaks in Bangladesh: Clinical Patterns, Emerging Risks, and Future Preparedness in an Expanding Epidemiologic Landscape

Abstract Background Nipah virus (NiV), a high-risk pathogen with pandemic potential, causes near-annual outbreaks in Bangladesh. Since January 2025, the Institute of Epidemiology, Disease Control and Research (IEDCR) and icddr,b have investigated three NiV outbreaks.Table 1:Demographic, Epidemiological, and Clinical Findings of Nipah Cases in the 2025 Outbreaks in BangladeshTable 2:Laboratory Test Results of Nipah Cases in the 2025 Outbreaks in Bangladesh Methods Structured and informal interviews with case families, contacts, and communities explored exposures, disease history, risk behaviors, possible spillover, and transmission routes. Oropharyngeal swabs and sera were tested in high-risk contacts and same-source exposed individuals for NiV RNA (RT-qPCR) and anti-NiV IgM (ELISA).Figure 1:Geospatial Mapping of Key Locations of the 2025 Nipah Outbreaks in Bangladesh Results Three sporadic NiV…