Journal ArticleOpen Access
Endothelial Dickkopf-1 Promotes Smooth Muscle Cell-derived Foam Cell Formation via USP53-mediated Deubiquitination of SR-A During Atherosclerosis
Authors
Author Affiliations
Ministry of Education, Chinese Academy of Medical Sciences & Peking Union Medical College, Shandong University, Qilu Hospital of Shandong University
Published InInternational Journal of Biological Sciences
Year2024
Citations8
Abstract
Our findings demonstrate that, endothelial DKK1, induced by pathological low shear stress, acts as an intercellular mediator, promoted the foam cell formation of SMCs. These results suggest that targeted intervention with endothelial DKK1 may confer beneficial effects on atherosclerosis.
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