S39 Polypharmacy in patients with non-cystic fibrosis bronchiectasis: the BRONCHUK observational study

<h3>Introduction</h3> BRONCHUK is a multicentre, prospective, observational cohort study enrolling adults with radiologically confirmed bronchiectasis across secondary centres in the UK. The objectives of the study are to develop a multicentre bronchiectasis registry incorporating baseline data collection with annual follow-up data for at least 5 years and to describe treatment patterns across the UK. Polypharmacy is defined as the concurrent use of ≥5 medications and has been rarely documented in literature for bronchiectasis patients. Polypharmacy has been associated with increased risk of adverse drug reactions and increased treatment burden. The current BTS guidelines have not detailed the impact of polypharmacy in bronchiectasis patients. <h3>Methods</h3> Adult patients with a clinical diagnosis of bronchiectasis supported by CT Thorax were recruited in the…