Role of hepcidin on benefits and risks of supplementation with iron syrup and multiple micronutrient powders in Bangladeshi children: a substudy to a randomized controlled trial

BACKGROUND: Hepcidin can determine individuals' responses to iron supplementation, but limited evidence exists from pediatric trials. OBJECTIVES: We aimed to examine the influence of hepcidin on the effects of supplementation with iron syrup and multiple micronutrient powders (MNPs) on hemoglobin and ferritin concentrations and the incidence of diarrhea in young children. METHODS: Participants included a subsample of 1281 8-mo-old children enrolled in a 3-arm, double-blind, double-dummy, individually randomized controlled trial examining the efficacy of 3 mo of universal supplementation with daily iron syrup (12.5 mg iron), MNPs (containing 12.5 mg iron), or placebo in children living in Bangladesh. In all participants at baseline, immediately postintervention (month 3), and after a further 9 mo of follow-up (month 12), serum hepcidin concentrations…