Kernel Weighted Least Square Approach for Imputing Missing Values of Metabolomics Data

Abstract Mass spectrometry is a modern and sophisticated high-throughput analytical technique that enables large-scale metabolomics analyses. It yields a high dimensional large scale matrix (samples × metabolites) of quantified data that often contain missing cell in the data matrix as well as outliers which originate from several reasons, including technical and biological sources. Although, in the literature, several missing data imputation techniques can be found, however all the conventional existing techniques can only solve the missing value problems but not relieve the problems of outliers. Therefore, outliers in the dataset, deteriorate the accuracy of imputation. To overcome both the missing data imputation and outlier’s problem, here, we developed a new kernel weight function based missing data imputation technique (proposed) that…