Unravelling <i>LRRK2</i> Pathways in Parkinson's Disease: Mechanisms and Intricacies

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms such as tremors, stiffness, and bradykinesia, as well as non-motor symptoms like cognitive impairment and mood swings. PD is a multifactorial disease comprised of environmental and genetic etiologies. In addition to family history, Variants in the &lt;i&gt;LRRK2&lt;/i&gt; gene are important as they represent the most common cause of familial PD and are also associated with some sporadic cases. The underlying causes of PD are also numerous and can be divided into a variety of environmental and genetic factors. This is the most relevant part because the LRRK2 gene Variant is one of the most common causes of familial Parkinson's disease, as well as contributing to sporadic cases beyond hereditary…