Journal ArticleOpen Access
Virulence Genes in Environmental Strains of <i>Vibrio cholerae</i>
Author Affiliations
National Institute of Cholera and Enteric Diseases, Indian Institute of Chemical Biology, National Institute of Infectious Diseases, Saitama International Medical Center, ...
Published InApplied and Environmental Microbiology
Year2000
Citations176
Abstract
The virulence of a pathogen is dependent on a discrete set of genetic determinants and their well-regulated expression. The ctxAB and tcpA genes are known to play a cardinal role in maintaining virulence in Vibrio cholerae, and these genes are believed to be exclusively associated with clinical strains of O1 and O139 serogroups. In this study, we examined the presence of five virulence genes, including ctxAB and tcpA, as well as toxR and toxT, which are involved in the regulation of virulence, in environmental strains of V. cholerae cultured from three different freshwater lakes and ponds in the eastern part of Calcutta, India. PCR analysis revealed the presence of these virulence genes or their homologues among diverse serotypes and ribotypes…
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