ReviewOpen Access
Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives
Author Affiliations
Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Ton Duc Thang University, University of Concepción, University of Medicine and Pharmacy of Craiova, ...
Published InFrontiers in Pharmacology
Year2020
Citations101
Abstract
The COVID-19 pandemic represents an unprecedented challenge for the researchers to offer safe, tolerable, and effective treatment strategies for its causative agent known as SARS-CoV-2. With the rapid evolution of the pandemic, even the off-label use of existing drugs has been restricted by limited availability. Several old antivirals, antimalarial, and biological drugs are being reconsidered as possible therapies. The effectiveness of the controversial treatment options for COVID-19 such as nonsteroidal antiinflammatory drugs, angiotensin 2 conversion enzyme inhibitors and selective angiotensin receptor blockers was also discussed. A systemic search in the PubMed, Science Direct, LitCovid, Chinese Clinical Trial Registry, and ClinicalTrials.gov data bases was conducted using the keywords "coronavirus drug therapy," passive immunotherapy for COVID-19', "convalescent plasma therapy," (CPT) "drugs for…
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