Journal ArticleUnknown
Increased peripheral blood mitochondrial DNA in type 2 diabetic patients with nephropathy
Author Affiliations
Diabetes UK, King's College London, Bangladesh Institute of Research and Rehabilitation for Diabetes Endocrine and Metabolic Disorders
Published InDiabetes Research and Clinical Practice
Year2009
Citations62
Abstract
We report that mitochondrial DNA (MtDNA) copy numbers are increased in peripheral blood of patients with diabetic nephropathy (DN). Using qPCR for quantitation, we found a 2-4-fold significant increase (p<0.05) in the mean MtDNA values in DN patients vs. healthy controls and diabetics without nephropathy. Increased MtDNA in DN could contribute to increased oxidative stress.
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