Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial

The article is reprinted after 'Lancet 2010; 376: 23-32' by the above collaborators with written permission from Lancet Authority.Background: Tranexamic acid can reduce bleeding in patients undergoing elective surgery. We assessed the effects of early administration of a short course of tranexamic acid on death, vascular ocdusive events, and the receipt of blood transfusion in trauma patients. Methods: This randomised controlled trial was undertaken in 274 hospitals in 40 countries. In Bangladesh we have taken 12 patients for this study. 20211 adult trauma patients with, or at risk of, significant bleeding were randomly assigned within 8 h of in jury to either tranexamic acid (loading dose 1 g over 10 mm then infusion of 1 g over 8 h) or…