COVID-19 chemoprevention

Despite the enormity of COVID-19 pandemic and the many hundreds of clinical trials evaluating putative therapeutics, there have been very few randomised controlled trials (RCTs) of COVID-19 pre-exposure prophylaxis. RCTs provide the strongest evidence in this setting (Collins et al., 2020Collins R. Bowman L. Landray M. Peto R. The magic of randomization versus the myth of real-world evidence.N Engl J Med. 2020; 382: 674-678Crossref PubMed Scopus (239) Google Scholar). This is particularly important in the politicised and febrile arena of COVID-19 medicines where claims and counter claims abound, and good clinical science has suffered. In this edition of IJID Seet et al. report a detailed and well conducted open cluster randomised trial of five different pre-exposure interventions in male migrant…