Phase Separation and Thermodynamic Behavior of Triton X-100 in the Occurrence of Levofloxacin Hemihydrates: Influence of Additives

Measurements of clouding phenomena in Triton X-100 (TX-100) were carried out in the aqueous system and the presence of the antibiotic drug levofloxacin hemihydrate (LFH)/(LFH + inorganic salts/alcohols) and were explained thoroughly. In the aqueous system, the observed values of cloud point (CP) of TX-100 increased continuously with the increasing concentration of TX-100. In the occurrence of LFH, the magnitudes of cloud point of a certain concentration of TX-100 were found to increase first, and after that, the CP value declined with increasing concentration of the drug. The magnitudes of CP for the LFH + TX-100 mixed system were found to be dwindled through the enrichment of salt concentration in the presence/absence of a drug (LFH). The CP values in…