Largest dengue outbreak of the decade with high fatality may be due to reemergence of DEN-3 serotype in Dhaka, Bangladesh, necessitating immediate public health attention

Dengue viruses (DENV) are arthropod-borne flaviviruses and are one of the most important causes of febrile illness in tropical and subtropical countries [1]. Globally, the frequency of dengue cases has increased tremendously over last the five decades along with the disease’s geographic expansion [2]. Nearly 75% of the dengue global disease burden is in the Southeast Asia and Western Pacific regions [3]. DENV comprises a group of four different viruses (serotypes DENV1–4), which are linked by serology, epidemiology and disease pathogenesis due to 25% to 40% heterogeneity at the amino acid level in virus envelope proteins [4]. All four serotypes are responsible for dengue epidemics. Infection with one of the serotypes confers serotype-specific lifelong immunity, but secondary infection with a…