Prostacyclin: A major prostaglandin in the regulation of adipose tissue development

Prostaglandins (PGs) belong to the group lipid mediators and can act as local hormones. They contain 20 carbon atoms, including a 5‐carbon ring, and are biosynthesized from membrane phospholipid derived arachidonic acid through the arachidonate cyclooxygenase (COX) pathway with the help of various terminal synthase enzymes. Prostacyclin (prostaglandin I 2 ) is one of the major prostanoids produced with the help of prostacyclin synthase (prostaglandin I 2 synthase) enzyme and rapidly hydrolyzed into 6‐keto‐PGF 1α in biological fluids. Obesity indicates an excess of body adiposity, which is globally considered as one of the major health disasters responsible for developing complex pathological situations in the human body. Adipose tissues can produce various PGs, and thus, the level and the molecular activity…