Late Breaking Abstract - Effects of a new airway clearance technology in children with cystic fibrosis - A homecare randomized controlled trial

<b>Introduction:</b> This trial aims to evaluate in children the&nbsp;effects&nbsp;of a new airway clearance technology (Simeox, Physio-Assist) added to optimal&nbsp;standard care (SC) including chest physiotherapy (CPT) at home. <b>Methods:</b> 40 pediatric patients (8-17 years) with clinically stable CF were randomized 1:1 in a cross-over trial: SC with (device) or without (control) Simeox. All patients&nbsp;performed&nbsp;CPT x3/day&nbsp;+ bronchodilators x2/day and were treated x2/day&nbsp;with&nbsp;Simeox in device group. After 1 month of therapy at home, patients switched on other study group for 1 additional month of therapy. Spirometry, body plethysmography (BP), Impulse oscillometry system (IOS), Lung Clearance Index (LCI), health-related quality of life (CFQ-R), side effects, tolerability, satisfaction were assessed during the study. <b>Results:</b> Baseline data: F/M 22/18, 13±3 y, BMI 19±3 kg/cm², FEV₁ 91±18%,…