A Scoping Review on Genetic Mutations and Single-Nucleotide Polymorphisms Associated with Pectus Excavatum

Santo Barman,1 Lana Momin,2 Rafiza Islam,3 Moung Shwe Shing,4 Redoy Ranjan,5,6 Benjamin Waterhouse,6 Joel Dunning6 1Department of Vascular Surgery, IBN Sina Specialized Hospital, Dhaka, Bangladesh; 2Sixth form, Haberdashers’ Girls’ School, Elstree, Hertfordshire, UK; 3Department of Vascular Surgery, St. Mary’s Hospital, London, UK; 4Department of Surgery, East Kent Hospital University NHS Foundation Trust, Canterbury, Kent, UK; 5Department of Cardiothoracic Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh; 6Department of Cardiothoracic Surgery, James Cook University Hospital, Middlesbrough, Cleveland, UKCorrespondence: Redoy Ranjan, Department of Cardiothoracic Surgery, James Cook University Hospital, Middlesbrough, UK, Email redoy_ranjan@bsmmu.edu.bdAbstract: Pectus excavatum (PE) is the most common congenital chest wall deformity, affecting approximately 1 in 400 live births, with a male predominance. While traditionally considered a primarily structural or…