Book ChapterUnknown
Enhanced Aqueous Solubility and Antibacterial Activity of Cefuroxime Axetil
Author Affiliations
University of Rajshahi
Published InBook Publisher International (a part of SCIENCEDOMAIN International)
Year2022
Abstract
The objective of this investigation was to improve the solubility and consequent antibacterial activity of cefuroxime axetil (CA), a \(\beta\) -lactamase-stable broad spectrum second generation cephalosporin through solid dispersion (SD) technique. CA loaded SDs (CSDs) were made using a solvent evaporation process with various amounts of microcrystalline cellulose (MCC) as a carrier. The characterization of CSDs was done by in-vitro dissolution study, thermal analysis (DSC), crystallinity (PXRD), interactions (FTIR) and morphology (SEM). With a drug-carrier (CA: MCC) ratio of 1:3, CSD-2 had the highest solubility rate among the formulations, 2.59 fold stronger than pure CA. DSC, PXRD, FTIR, and SEM investigations confirmed that the increased dissolution rate was due to drug conversion from crystalline to amorphous form during SDs production.…
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Fields & Keywords
Life SciencesBiochemistry, Genetics and Molecular BiologyMolecular MedicineAntibiotic Resistance in BacteriaPhenothiazines and Benzothiazines Synthesis and ActivitiesAntibiotics Pharmacokinetics and EfficacyNuclear chemistryChemical engineeringOrganic chemistryPharmacologyBiochemistryCrystallographyGenetics