Effects of <i>Ganoderma lucidum</i> Supplementation on Obesity and Metabolic Alterations Induced by High‐Carbohydrate‐High‐Fat Diet in Rats

Ganoderma lucidum (GL), commonly called Reishi mushroom, has been utilized in traditional medicine against multiple ailments including obesity and metabolic complications. The purpose of this study was to evaluate the ability of the powdered supplementation of GL (2.5% w/w of diet) and its ability to ameliorate obesity and associated metabolic alterations in high‐carbohydrate‐high‐fat (HCHF) diet–fed obese female Wistar rats. Thus, after 56 days of feeding the mice with different treatments, we measured physiological parameters to evaluate the effect. Phytochemical analysis by HPLC identified the bioactive polyphenols in GL. Results demonstrated that GL supplementation significantly ( p &lt; 0.05) prevented the net rise in body weight and reduced organ weights and abdominal fat deposition in obese rats. It improved glucose intolerance,…