Haijun Liu, Shencun Fang, Wei Wang, Yusi Cheng et al.
Silicosis is characterized by accumulation of fibroblasts and excessive deposition of extracellular matrix. Monocyte chemotactic protein-1-induced protein 1 (MCPIP1) plays a critical role in fibrosis induced by SiO2. However, the details of the downstream events of MCPIP1 activity in pulmonary fibro...
Molin Yang, Xiang Wei, Xin Yi, Ding‐Sheng Jiang
During oxidative phosphorylation, mitochondria continuously produce reactive oxygen species (ROS), and untimely ROS clearance can subject mitochondria to oxidative stress, ultimately resulting in mitochondrial damage. Mitophagy is essential for maintaining cellular mitochondrial quality control and ...
Md. Ataur Rahman, Moon Nyeo Park, MD Hasanur Rahman, Md Mamunur Rashid et al.
The key tumor suppressor protein p53, additionally known as p53, represents an attractive target for the development and management of anti-cancer therapies. p53 has been implicated as a tumor suppressor protein that has multiple aspects of biological function comprising energy metabolism, cell cycl...
Tiebing Zhu, Qi Yao, Wei Wang, Honghong Yao et al.
BACKGROUND/AIMS: Inducible nitric oxide synthase (iNOS) plays a crucial role in ischemia/reperfusion (I/R). Autophagy is involved in irreversible cell injury and death under extreme conditions. However, whether iNOS mediates myocardial ischemia/reperfusion (I/R) injury in endothelial cells via autop...
Christian Seitz, Manuela Hugle, Silvia Cristofanon, Aurélie Tchoghandjian et al.
On the basis of our previous identification of aberrant phosphatidylinositol-3-kinase (PI3K)/Akt signaling as a novel poor prognostic factor in neuroblastoma, we evaluated the dual PI3K/mTOR inhibitor BEZ235 in the present study. Here, BEZ235 acts in concert with the lysosomotropic agent chloroquine...
Md. Abdul Hannan, Md. Ataur Rahman, Md Saidur Rahman, Abdullah Al Mamun Sohag et al.
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative pathogen of deadly Coronavirus disease-19 (COVID-19) pandemic, which emerged as a major threat to public health across the world. Although there is no clear gender or socioeconomic discrimination in the incidence of COVID-...
Md. Ataur Rahman, Subbroto Kumar Saha, Md Saidur Rahman, Md Jamal Uddin et al.
Autophagy, a cellular self-digestion process that is activated in response to stress, has a functional role in tumor formation and progression. Cancer stem cells (CSCs) accounting for a minor proportion of total cancer cells-have distinct self-renewal and differentiation abilities and promote metast...
Tomoyuki Sasaki, Shanshan Lian, Alam Khan, Jesse R. Llop et al.
transporting, lysosomal, V0 subunit ca) led to suppression of the senescence induced by the Spns1 defect, whereas the sole loss of Atp6v0ca led to senescent embryos similar to the single spns1 mutation. Moreover, we discovered that the combined stable defect seen in the presence of both the spns1 an...
Yongqiang Chen, Pengcheng Li, Ning Pan, Rong Gao et al.
<h3>Background</h3> CD4<sup>+</sup> T cells are critical effectors of anti-tumor immunity, but how tumor cells influence CD4<sup>+</sup> T cell effector function is not fully understood. Tumor cell-released autophagosomes (TRAPs) are being recognized as critical modulators of host anti-tumor immunit...
Md. Ataur Rahman, Md Saidur Rahman, MD. Hasanur Rahman, Mohammad Rasheduzzaman et al.
Alzheimer's disease (AD) is characterized by the formation of intracellular aggregate composed of heavily phosphorylated tau protein and extracellular deposit of amyloid-β (Aβ) plaques derived from proteolysis cleavage of amyloid precursor protein (APP). Autophagy refers to the lysosomal-mediated de...
Md. Ataur Rahman, Md Rezanur Rahman, Toyfiquz Zaman, Md. Sahab Uddin et al.
BACKGROUND: Naturally-occurring products derived from living organisms have been shown to modulate various pharmacological and biological activities. Natural products protect against various diseases, which could be used for therapeutic assistance. Autophagy, a lysosome-mediated self-digestion pathw...
Guo Zhao, Junfeng Zhen, Xinyuan Liu, J.J. Guo et al.
Lysine succinylation (Ksuc) is a novel protein post-translational modification (PTM) wherein a succinyl group modifies a lysine residue. Ksuc leads to significant chemical and structural changes to the modified protein. Recent studies have shown that Ksuc might play an important role in organism phy...
Md. Ataur Rahman, MD. Hasanur Rahman, Md. Shahadat Hossain, Partha Biswas et al.
Autophagy is a vacuolar, lysosomal degradation pathway for injured and damaged protein molecules and organelles in eukaryotic cells, which is controlled by nutrients and stress responses. Dysregulation of cellular autophagy may lead to various diseases such as neurodegenerative disease, obesity, car...
Yi Zhao, Muzi Li, Milton Talukder, Yu Luo et al.
Di(2-ethylhexyl) phthalate (DEHP) is a widespread environmental contaminant, which is mainly used as a plasticizer to improve the flexibility of products; however, its extensive use causes male reproductive damage. Lycopene (LYC) has a protective effect on male reproductive toxicity. Nevertheless, t...
Xiao Qiang Xie, Pei Zhang, Bo Tian, Xiaoqian Chen
Sirtuin 2 (SIRT2) is a member of NAD + -dependent protein deacetylases involved in a wide range of pathophysiological processes including myocardial injury, Parkinson's disease, and Huntington's disease. However, the direct implication of SIRT2 in ischemic stroke is still unclear. In the present stu...