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Field: Berberine and alkaloids research

Prophetic medicine as potential functional food elements in the intervention of cancer: A review

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Bassem Y. Sheikh, Md. Moklesur Rahman Sarker, Muhamad Noor Alfarizal Kamarudin, Amin Ismail

Journal: Biomedicine & Pharmacotherapy
Year: 2017
Citations: 46

Amounting scientific evidences have revealed the antitumor, antimetastatic, antiangiogenic, antiproliferative, chemopreventive and neo-adjuvant efficacy of Prophetic Medicine in various in vitro, in vivo and clinical cancer models. Prophetic Medicine includes plants, dietary materials or spices that...

Health SciencesMedicinePharmacology
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Hepatoprotective Role of Hydrangea macrophylla against Sodium Arsenite-Induced Mitochondrial-Dependent Oxidative Stress via the Inhibition of MAPK/Caspase-3 Pathways

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Md Rashedunnabi Akanda, Hyun‐Jin Tae, In‐Shik Kim, Dongchoon Ahn et al.

Journal: International Journal of Molecular SciencesYear: 2017Citations: 44

Sodium arsenite (NaAsO2) has been recognized as a worldwide health concern. Hydrangea macrophylla (HM) is used as traditional Chinese medicine possessing antioxidant activities. The study was performed to investigate the therapeutic role and underlying molecular mechanism of HM on NaAsO2-induced tox...

Life SciencesPharmacology, Toxicology and PharmaceuticsPharmacologyOpen Access
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Cryptolepine, isolated from <i>Sida acuta</i>, sensitizes human gastric adenocarcinoma cells to TRAIL‐induced apoptosis

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Firoj Ahmed, Kazufumi Toume, Takashi Ohtsuki, Mahmudur Rahman et al.

Journal: Phytotherapy ResearchYear: 2010Citations: 43

Bioassay guided separation of Sida acuta whole plants led to the isolation of an alkaloid, cryptolepine (1), along with two kaempferol glycosides (2-3). Compound 1 showed strong activity in overcoming TRAIL-resistance in human gastric adenocarcinoma (AGS) cells at 1.25, 2.5 and 5 μm. Combined treatm...

Life SciencesBiochemistry, Genetics and Molecular BiologyMolecular Biology
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Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical Potentials

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Mazdida Sulaiman, Khoshnur Jannat, Veeranoot Nissapatorn, Mohammed Rahmatullah et al.

Journal: AntibioticsYear: 2022Citations: 41

The emergence of multidrug-resistant bacteria and fungi requires the development of antibiotics and antifungal agents. This review identified natural products isolated from Asian angiosperms with antibacterial and/or antifungal activities and analyzed their distribution, molecular weights, solubilit...

Health SciencesMedicinePharmacologyOpen Access
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Maintenance of glycaemic control with the evening administration of a long acting sulphonylurea in male type 2 diabetic patients undertaking the Ramadan fast

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Abdul Hamid Zargar, Morshed Bin Siraj, Ali Jawa, Md Zahid Hasan et al.

Journal: International Journal of Clinical PracticeYear: 2010Citations: 38

BACKGROUND: In Ramadan, misuse of hypoglycaemic agents, alterations in diet and hypoglycaemia are frequent. This study assessed whether switching to an evening administration of a long acting sulphonylurea during the 29-day, dawn to dusk fast, can maintain glycaemic control in patients with type 2 d...

Health SciencesMedicinePhysiology
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Inhibitory effects of an aqueous extract from Cortex Phellodendri on the growth and replication of broad-spectrum of viruses in vitro and in vivo

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Jae Hoon Kim, Prasanna Weeratunga, Myun Soo Kim, Chamilani Nikapitiya et al.

Journal: BMC Complementary and Alternative MedicineYear: 2016Citations: 37

BACKGROUND: Cortex Phellodendri (C. Phellodendri), the dried trunk bark of Phellodendron amurense Ruprecht, has been known as a traditional herbal medicine, showing several bioactivities. However, antiviral activity of C. Phellodendri aqueous extract (CP) not reported in detail, particularly aiming ...

Health SciencesMedicinePharmacologyOpen Access
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The anti-inflammatory effects of an ethanolic extract of the rhizome of Atractylodes lancea, involves Akt/NF-κB signaling pathway inhibition

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Muhammad Jahangir Hossen, Aftab Amin, Xiu‐Qiong Fu, Ji‐Yao Chou et al.

Journal: Journal of EthnopharmacologyYear: 2021Citations: 35

Ethnopharmacological relevance The dried rhizome of Atractylodes lancea (Thumb.) DC. (Compositae) has been prescribed in folk medicine for the management of various inflammatory conditions such as rheumatic diseases, gastritis and hepatitis. However, the molecular mechanisms underlying the beneficia...

Health SciencesMedicineComplementary and alternative medicine
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In vivo sedative activity of methanolic extract of Stericulia villosa Roxb. leaves

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Md. Forhad Hossain, Bashudeb Talukder, Mohammad Nasiruddin Rana, Refat Tasnim et al.

Journal: BMC Complementary and Alternative MedicineYear: 2016Citations: 34

BACKGROUND: This plant is very popular ingredient of local made drinks during hot summer. After drinking this drink people feels fresh, relaxed and can enjoy sound sleep. Present study was aimed to assess the sedative properties of a plant Sterculia villosa leaves. Therefore, we tried to find out th...

Life SciencesAgricultural and Biological SciencesFood ScienceOpen Access
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Chemistry and Biological Activities of<i>Berberis lycium</i>Royle

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Hazrat Ali, Shahab Uddin, Sajid Jalal

Journal: Journal of Biologically Active Products from NatureYear: 2015Citations: 31

AbstractBerberis lycium Royle belonging to family Berberidaceae is a high-value medicinal plant with a known history of uses in folk medicine. It is used traditionally for curing a broad range of human illnesses and diseases in the Indian Himalayan region of Pakistan, India, and Bangladesh. Its ethn...

Health SciencesMedicinePharmacology
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A spotlight on alkaloid nanoformulations for the treatment of lung cancer

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S. M. Sindhoor, N. Raghavendra Naveen, GSN Koteswara Rao, Gopika Gopan et al.

Journal: Frontiers in OncologyYear: 2022Citations: 28

Numerous naturally available phytochemicals have potential anti-cancer activities due to their vast structural diversity. Alkaloids have been extensively used in cancer treatment, especially lung cancers, among the plant-based compounds. However, their utilization is limited by their poor solubility...

Health SciencesMedicinePharmacologyOpen Access
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Antinociceptive effect of ethanol extract of leaves of Lannea coromandelica

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Mohammad Zafar Imam, Md. Moniruzzaman

Journal: Journal of EthnopharmacologyYear: 2014Citations: 28

Ethnopharmacological relevance Lannea coromandelica (Houtt.) Merr. is a plant locally called "Jiga", found all over Bangladesh. Leaf of the plant is traditionally used in the treatment of local swellings, pains of body, toothache etc. This study evaluated the antinociceptive effect of the ethanol ex...

Life SciencesAgricultural and Biological SciencesPlant Science
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Medicinal Plants Used as an Alternative to Treat Gingivitis and Periodontitis

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Neeraj Rani, Rajeev K. Singla, Sonia Narwal, Tanushree Tanushree et al.

Journal: Evidence-based Complementary and Alternative MedicineYear: 2022Citations: 27

For various ailments, natural remedies have been traditionally used. To defend against common disorders, medicinal plants are progressively used as nutritional supplements. Gingivitis and periodontitis are widespread and can affect most of the world's population. Gingivitis is a very common, nondest...

Life SciencesPharmacology, Toxicology and PharmaceuticsPharmacologyOpen Access
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Alkaloid-based modulators of the PI3K/Akt/mTOR pathway for cancer therapy: Understandings from pharmacological point of view

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Fatima Zohra Mokhfi, Md. Al Amin, Mehrukh Zehravi, Sherouk Hussein Sweilam et al.

Journal: Chemico-Biological InteractionsYear: 2024Citations: 25

This review aims to summarize the role of alkaloids as potential modulators of the PI3K/Akt/mTOR (PAMT) pathway in cancer therapy. The PAMT pathway plays a critical role in cell growth, survival, and metabolism, and its dysregulation contributes to cancer hallmarks. In healthy cells, this pathway is...

Health SciencesMedicinePharmacology
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Phyto‐pharmacological perspective of Silymarin: A potential prophylactic or therapeutic agent for <scp>COVID</scp>‐19, based on its promising immunomodulatory, anti‐coagulant and anti‐viral property

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Partha Palit, Aparna Mukhopadhyay, Debprasad Chattopadhyay

Journal: Phytotherapy ResearchYear: 2021Citations: 23

Coronavirus disease 2019 (COVID-19) triggered by a new viral pathogen, named severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), is now a global health emergency. This debilitating viral pandemic not only paralyzed the normal daily life of the global community but also spread rapidly via g...

Health SciencesMedicinePulmonary and Respiratory MedicineOpen Access
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Perceptions of the Muslim religious leaders and their attitudes on herbal medicine in Bangladesh: a cross-sectional study

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Md. Harun‐Or‐Rashid, Yoshitoku Yoshida, Md Aminur Rashid, Salmun Nahar et al.

Journal: BMC Research NotesYear: 2011Citations: 23

BACKGROUND: Herbal Medicines (HMs) are playing major roles in the health of the millions of people worldwide. Muslim Religious Leader (MRLs), being an important component of the society with huge influence on it, could contribute a lot to promote HM. This study was aimed at evaluating perceptions of...

Health SciencesMedicineComplementary and alternative medicineOpen Access
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