Mamun Al‐Amin, Mir Muhammad Nasir Uddin, Hasan Mahmud Reza
OBJECTIVE: We investigated the effects of antipsychotics on immune-challenged peripheral blood mononuclear cell (PBMC) cultures. METHODS: Blood samples were collected from twelve patients with first-episode schizophrenia. The PBMCs were separated and cultures were prepared and stimulated with lipopo...
Rajesh Das, Md. Prova Zaman Emon, Mohammad Shahriar, Zabun Nahar et al.
Major depressive disorder (MDD) is a debilitating psychiatric disease. The dysregulated cytokines in depression are assumed due to the hyperactivation of the immune system. Here we aimed to evaluate the serum interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in MDD. This study recruited 87 ...
Mohammed Abu Tayab, Mohammad Nazmul Islam, Kazi Ashfak Ahmed Chowdhury, Farhin Muntaha Tasnim
Depression is the most prevalent and debilitating mental disorder that affects a substantial number of people globally, hindering all aspects of their lives and leading to a high number of suicides each year. Despite the availability of an array of antidepressant medications, taking these medication...
Sadia Anjum, M. M. A. Shalahuddin Qusar, Mohammad Shahriar, Sardar Mohammad Ashraful Islam et al.
Background: Abnormal expression of inflammatory cytokines in major depressive disorder (MDD) suggests the activation of an inflammatory process. The pattern of alterations in cytokine levels is still ambiguous. The present study aimed to evaluate interleukin-7 (IL-7) and interleukin-10 (IL-10) for t...
Md. Rabiul Islam, Samia Ali, James Regun Karmoker, Mohammad Fahim Kadir et al.
BACKGROUND: The alterations of biological markers are thought to be effective tools to understand the pathophysiology and management of major depressive disorder (MDD). A lot of researches has implied many markers for depression, but any of them fully discovered the association between the markers a...
Nuruna Lovely Nishuty, Md. Mehedi Hasan Khandoker, James Regun Karmoker, Sumiya Ferdous et al.
Background Major depressive disorder (MDD) is a disabling health problem with a very high global prevalence and burden. Alteration of inflammatory markers in depression is of growing interest to many psychiatry researchers. This study aimed to examine the serum levels of interleukin-6 (IL-6) and C-r...
Stephen Cooper, John G. Kelly, David J. King
Platelet alpha 2-and lymphocyte beta 2-adrenoceptor densities, plasma noradrenaline and serum cortisol were measured before, during and one week after a course of EEG-monitored electroconvulsive therapy, in nine depressed patients. A 50% fall in Hamilton Depression Rating scores occurred after a fai...
Tarapati Rana, Tapan Behl, Vineet Mehta, Md. Sahab Uddin et al.
Depression is a common psychiatric disorder, the exact pathogenesis of which is still elusive. Studies have proposed that immunity disproportion and enhancement in proinflammatory cytokines might be linked with the development of depression. HMGB1 (High-mobility group box (1) protein has obtained mo...
Ying Bai, Yang Cai, Di Chang, Daxing Li et al.
Depression stands as a prominent contributor to global disability, entailing an elevated risk of suicide. Substantial evidence supports the notion that immune dysregulation may play a role in the development of depression and impede responses to antidepressant treatments. Immune dysregulation may ca...
Sohel Daria, Maliha Afrin Proma, Mohammad Shahriar, Sardar Mohammad Ashraful Islam et al.
Objectives: Major depressive disorder is a leading heterogeneous psychiatric illness manifested by persistent low mood, a feeling of sadness, and diminished interest in daily activities. Many biological, genetic, and social factors are thought to be linked with depression. But any suitable early ris...
Xiangning Chen, Cuie Sun, Qi Chen, F. Anthony O’Neill et al.
BACKGROUND: Apoptosis has been speculated to be involved in schizophrenia. In a previously study, we reported the association of the MEGF10 gene with the disease. In this study, we followed the apoptotic engulfment pathway involving the MEGF10, GULP1, ABCA1 and ABCA7 genes and tested their associati...
Minghuan Zhu, Zhenjing Liu, Yanhong Guo, Sadia Sultana et al.
Abstract Background Increasing evidence indicates that dysregulated TNF-α and oxidative stress (OxS) contribute to the pathophysiology of schizophrenia. Additionally, previous evidence has demonstrated sex differences in many aspects of schizophrenia including clinical characteristics, cytokines, an...
Md. Mamun Al-Amin, Md. Faiyad Rahman Choudhury, Al Saad Chowdhury, Tahsinur Rahman Chowdhury et al.
Risperidone (RIS), an atypical antipsychotic has been found to show anti-inflammatory effect against lipopolysaccharide (LPS)-induced inflammation. In-vitro study has revealed that RIS inhibits the LPS-induced reactive oxygen species (ROS) formation. We investigated the antioxidant effects of RIS on...
Wanze Xie, Swapna Kumar, Shahria Hafiz Kakon, Rashidul Haque et al.
BACKGROUND: Early exposure to inflammation in childhood is increasingly recognized as one of the major factors that hinder millions of children worldwide from meeting their full developmental potential. The current study examined the association between systemic inflammation and children's neural re...
Mehedi Hasan Bappi, Md. Nayem Mia, Siddique Akber Ansari, Irfan Aamer Ansari et al.
Abstract Quercetin is the most common polyphenolic flavonoid present in fruits and vegetables demonstrating versatile health‐promoting effects. This study aimed to examine the effects of quercetin (QR) and sclareol (SCL) on the thiopental sodium (TS)‐induced sleeping and forced swimming test (FST) m...