Sriram Krishnaswamy, W R Church, Michael E. Nesheim, Kenneth G. Mann
The kinetics of the activation of human prothrombin catalyzed by human prothrombinase was studied using the fluorescent alpha-thrombin inhibitor dansylarginine-N-(3-ethyl-1,5-pentanediyl)amide (DAPA). Prothrombinase proteolytically activates prothrombin to alpha-thrombin by cleavages at Arg273-Thr27...
Zhengyuan Cheng, Manoj Hang Limbu, Zhi Wang, Jing Liu et al.
Gelatinases are members of the matrix metalloproteinase (MMPs) family; they play an important role in the degradation of the extracellular matrix (ECM). This effect is also crucial in the development and progression of chronic kidney disease (CKD). Its expression, as well as its activity regulation ...
Gary E. Raskob, Harry R. Büller, Martin H. Prins, Annelise Segers et al.
Background New oral anticoagulants may simplify long-term therapy by eliminating the need for laboratory monitoring. Edoxaban is an oral, direct inhibitor of factor Xa that is given in a fixed dose once daily. Objective and methods The Hokusai-VTE study is a randomized, double-blind trial to evaluat...
Julio C. Furlan, Michael G. Fehlings
STUDY DESIGN: Systematic review. OBJECTIVE: To examine the evidence to support practice guidelines for screening for DVT in asymptomatic adults with acute traumatic spinal cord injury (SCI) who undergo pharmacologic thromboprophylaxis. SUMMARY OF BACKGROUND DATA: Despite the fact that pharmacologic ...
Guy L. Reed, Gary R. Matsueda, Eldad Haber
Recent experiments in vitro have shown that inhibition of human alpha 2-antiplasmin by a monoclonal antibody (MAb RWR) markedly enhances clot lysis by plasminogen activators. To extend these studies in vivo, we tested whether inhibition of clot or fibrin-bound alpha 2-antiplasmin by MAb RWR could en...
Mahbubur Rahman, Abdus Samad Chowdhury, Tsuguya Fukui, Kenji Hira et al.
BACKGROUND: In addition to cigarettes, bidi, made of unprocessed and low-grade tobacco, is being smoked widely in Bangladesh and in other south Asian countries. The cause-and-effect relationship is established between thromboangiitis obliterans (TAO) and smoking. However, type of smoking material(s)...
Md Asiful Islam, Shahad Saif Khandker, Fahmida Alam, Mohammad Amjad Kamal et al.
Background Antiphospholipid Syndrome (APS) is an autoimmune multifactorial disorder. Genetics is believed to play a contributory role in the pathogenesis of APS, especially in thrombosis development and pregnancy morbidity. In the last 20 years, extensive research on genetic contribution on APS indi...
AM Hossain, NU Ahmed, Mahbubur Rahman, Mohammad Rashedul Islam et al.
A hospital based cross sectional study was carried out to analyze prevalence of risk factors for stroke in hospitalized patient in a medical college hospital. 100 patients were chosen using purposive sampling technique. Highest incidence of stroke was between the 6th and 7th decade. Patients came fr...
Farrah J. Mateen, Marco Carone, Nurul Alam, Peter Kim Streatfield et al.
BACKGROUND AND PURPOSE: There are limited population-based studies to determine the risk factors for stroke in Bangladesh. METHODS: A health and demographic surveillance system has been maintained in Matlab, Bangladesh (population 223 886, 142 villages in 2008). All adult stroke and injury deaths (2...
Juliana Abboud, Abir Abdel Rahman, Lara A Kahale, Martin Dempster et al.
BACKGROUND: Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in hospitalized patients. Numerous VTE prevention clinical practice guidelines are available but not consistently implemented. This systematic review explored effectiveness of implementing VTE prevention clinical ...
Mia Golder, Jeffrey Mewburn, David Lillicrap
Factor VIII (FVIII), a procoagulant cofactor, plays a crucial role in the intrinsic coagulation cascade. A causal association between elevated FVIII levels and venous thrombosis incidence has been established; no such association has been confirmed with arterial thrombosis. The independent role of e...
Yanping Wu, Chao Wang, Jiaqi Guo, Abdlay Carvalho et al.
was synthesized by sequential modification of PEGylated TTQ, followed by c(RGD) condensation. Signal strength was continuously monitored for 24 h following TTQ-PEG-c(RGD) or non-specific fluorescent dye injection. The contralateral external jugular vein, sham surgery and a competitive inhibition exp...
Qiong‐Dan Zhang, Qiu‐Yi Duan, Jing Tu, Fu‐Gen Wu
Thrombin, a coagulation-inducing protease, has long been used in the hemostatic field. During the past decades, many other therapeutic uses of thrombin have been developed. For instance, burn treatment, pseudoaneurysm therapy, wound management, and tumor vascular infarction (or tumor vasculature blo...
Bikram Prasad Gajurel, Gaurav Nepal, Vikash Jaiswal, Song Peng Ang et al.
BACKGROUND: Despite intravenous thrombolysis (IVT) being used for the treatment of acute ischemic stroke (AIS) for over two decades, its accessibility remains limited in various regions of the world. The Asian region, which experiences the highest age-standardized incidence of AIS, currently lacks c...
Julie Maes
<i>Candida auris</i> was discovered in 2009 and has rapidly emerged as a serious public health threat with cases reported in over 20 countries worldwide. As of May 8, 2020, the Centers for Disease Control and Prevention reported a total of 1122 US cases. <i>C. auris</i> is often multidrug resistant,...