Samuel Gebremedhn, Dessie Salilew‐Wondim, Ijaz Ahmad, Sudeep Sahadevan et al.
In bovine, ovarian follicles grow in a wave-like fashion with commonly 2 or 3 follicular waves emerging per estrous cycle. The dominant follicle of the follicular wave which coincides with the LH-surge becomes ovulatory, leaving the subordinate follicles to undergo atresia. These physiological proce...
Jan Smida, Hongen Xu, Yanping Zhang, Daniel Baumhoer et al.
Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. It is characterized by highly complex karyotypes with structural and numerical chromosomal alterations. The observed OS-specific characteristics in localization and frequencies of chromosomal breakages str...
Mohammad Shoeb, Stephen M. MacManus, Marcel Jaspars, Jioji Trevidu et al.
Zongwei Lin, Junfeng Ge, Zhe Wang, Jianwei Ren et al.
The inflammatory responses of vascular endothelial cells (VECs) are critical in the development of many cardio-cerebrovascular diseases. Let-7e is an important regulator of endothelial function and inflammation. However, the effects and mechanisms of let-7e on VECs inflammation have not been studied...
Dessie Salilew‐Wondim, Ijaz Ahmad, Samuel Gebremedhn, Sudeep Sahadevan et al.
This study aimed to investigate the miRNA expression patterns in granulosa cells of subordinate (SF) and dominant follicle (DF) during the early luteal phase of the bovine estrous cycle. For this, miRNA enriched total RNA isolated from granulosa cells of SF and DF obtained from heifers slaughtered a...
Zhidong Yuan, Xiao Sun, Hongde Liu, Jianming Xie
MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression by targeting mRNAs for translation repression or mRNA degradation. Many miRNAs are being discovered and studied, but in most cases their origin, evolution and function remain unclear. Here, we characterized miRNAs d...
Pihai Gong, Fengchang Qiao, Huazhang Wu, He Cui et al.
Increasing studies showed that long-noncoding RNAs (lncRNAs) play important roles in the biological processes, including cancer initiation and progression. However, little is known about the exact role and regulation mechanism of lncRNA UCA1 during the progression of gastric cancer (GC). In this stu...
Melanie J. Percy, Mary Frances McMullin, Simon N. Jowitt, Michael F. Potter et al.
The Chuvash form of polycythemia is an autosomal recessive disorder common to a large number of families in central Russia. Affected individuals have been reported to be homozygous for an Arg200Trp mutation in the von Hippel-Lindau (VHL) gene. We have screened 78 patients with erythrocytosis and fou...
Samir Kumar Sadhu, Emi Okuyama, Haruhiro Fujimoto, Masami Ishibashi et al.
As Cistus laurifolius has been used traditionally to treat inflammatory and rheumatic disorders, its leaves were tested for prostaglandin (PG) inhibitory and antioxidant activities. The leaf extract showed both activities, i.e., inhibitory effect at 300 microg/ml on PGE1- and E2-induced contractions...
Xiangxiang Liu, Xiaoxiang Chen, Kaixuan Zeng, Mu Xu et al.
As one of the most common cancers worldwide, colorectal cancer (CRC) causes a large number of mortality annually. Aberrant expression of microRNAs (miRNAs) is significantly associated with the initiation and development of CRC. Further investigations regarding the regulatory mechanism of miRNAs is w...
Yoon‐Beom Lee, Jung Ki Min, Jae‐Gyu Kim, Kim Cuong et al.
Glucose metabolism is a mechanism by which energy is produced in form of adenosine triphosphate (ATP) by mitochondria and precursor metabolites are supplied to enable the ultimate enrichment of mature metabolites in the cell. Recently, glycolytic enzymes have been shown to have unconventional but im...
Md. Ali Hossain, Sheikh Mohammed Shariful Islam, Julian M.W. Quinn, Fazlul Huq et al.
Ovarian cancer (OC) is a common cause of cancer death among women worldwide, so there is a pressing need to identify factors influencing OC mortality. Much OC patient clinical data is publicly accessible via the Broad Institute Cancer Genome Atlas (TCGA) datasets which include patient age, cancer si...
Mei Cao, Huaqing Li, Jian Zhao, Juan Cui et al.
Alzheimer’s disease (AD) is an age- and gender-associated brain disorder. Long noncoding RNAs (lncRNAs) have emerged as key regulators of brain development, homeostasis, and pathologies. Here we utilized gene array datasets and bioinformatics analysis to identify differentially-expressed age- and ge...
Donny van der Meer, Mari L. Uchimoto, Graham Williams
Micro-RNAs (miRNAs) can be specifically expressed in forensically relevant body fluids such as blood or saliva. The aim of the study was to develop a simultaneous extraction and analysis protocol that allows for the acquisition of a DNA profile and the identity of the body fluid using a single proce...
Hideo Tsuboi, Khaled Hossain, Anwarul Azim Akhand, Kozue Takeda et al.
Paeoniflorin (PF), isolated from paeony root, has been used as a herbal medicine for more than 1,200 years in China, Korea, and Japan for its anti-allergic, anti-inflammatory, and immunoregulatory effects. In this study, we found that PF induces apoptosis in both murine T-lineage cells and human T-c...