Allison M. Pritchett, Douglas W. Mahoney, Steven J. Jacobsen, Richard J. Rodeheffer et al.
Objectives We examined the association between diastolic function and left atrial volume indexed to body surface area (LAVi) in a population-based study. Background Atrial enlargement has been suggested as a marker of the severity and duration of diastolic dysfunction (DD). However, the association ...
David H. Birnie, Jeff S. Healey, George A. Wells, Atul Verma et al.
BACKGROUND: Many patients requiring pacemaker or implantable cardioverter-defibrillator (ICD) surgery are taking warfarin. For patients at high risk for thromboembolic events, guidelines recommend bridging therapy with heparin; however, case series suggest that it may be safe to perform surgery with...
Paolo Zanoni, Sumeet A. Khetarpal, Daniel B. Larach, William Hancock‐Cerutti et al.
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower risk of coronary heart disease (CHD). Mice that have depleted Scarb1 (SR-BI knockout mice) have markedly elevated HDL-C l...
Md. Mamun Ali, Bikash Kumar Paul, Kawsar Ahmed, Francis M. Bui et al.
Machine learning and data mining-based approaches to prediction and detection of heart disease would be of great clinical utility, but are highly challenging to develop. In most countries there is a lack of cardiovascular expertise and a significant rate of incorrectly diagnosed cases which could be...
Simon Yadgir, Catherine O. Johnson, Victor Aboyans, Oladimeji Adebayo et al.
BACKGROUND: Nonrheumatic valvular diseases are common; however, no studies have estimated their global or national burden. As part of the Global Burden of Disease Study 2017, mortality, prevalence, and disability-adjusted life-years (DALYs) for calcific aortic valve disease (CAVD), degenerative mitr...
John G. Canto, Nathan R. Every, David J. Magid, William J. Rogers et al.
BACKGROUND: There is an inverse relation between mortality from cardiovascular causes and the number of elective cardiac procedures (coronary angioplasty, stenting, or coronary bypass surgery) performed by individual practitioners or hospitals. However, it is not known whether patients with acute my...
Paul McKeigue, J. E. Ferrie, T. Pierpoint, Michael Marmot
BACKGROUND: Rates of coronary heart disease are higher in South Asians (Indians, Pakistanis, and Bangladeshis) settled overseas than in other ethnic groups. We tested the hypothesis that this excess risk results from metabolic disturbances associated with insulin resistance. METHODS AND RESULTS: The...
Oliver Guttmann, Mohammad Shafiqur Rahman, Constantinos O’Mahony, Aris Anastasakis et al.
CONTEXT: HCM is commonly associated with AF. Current guidelines for AF management omit detailed advice for HCM because of a lack of clinical prediction tools that estimate the risk of developing AF and an absence of adequately powered treatment studies. OBJECTIVE: To critically review current litera...
CARDIoGRAMplusC4D, Joanna M. M. Howson, EPIC-CVD, Wei Zhao et al.
Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await identification. An efficient discovery strategy may...
Guy Van Camp, Anja Flamez, Bernard Cosyns, Caroline Weytjens et al.
Background Restrictive valvular heart disease has been reported in patients with Parkinson's disease treated with pergolide. However, few data are available on frequency, severity, dose dependency, and reversibility of pergolide-induced disease, nor on the pulmonary pressures of these patients. We a...
Melinda Davis, Bijoy K. Menon, Leyla Baghirzada, Cynthia Resende Campos-Herrera et al.
BACKGROUND: Studies of endovascular treatment for acute ischemic stroke have identified general anesthesia as a predictor for poor outcome in comparison with local anesthesia/sedation. This retrospective study attempts to identify modifiable factors associated with poor outcome, while adjusting for ...
Lili Zhang, Daniel A. Zlotoff, Magid Awadalla, Syed Mahmood et al.
Introduction: myocarditis is a potentially fatal complication of immune checkpoint inhibitors (ICI). While corticosteroids are the cornerstones of the treatment, there are no data to guide the dose and timing.\n\nMethods: from an international registry of patients with ICI myocarditis diagnosed betw...
Safial Islam Ayon, Md. Milon Islam, Md Rahat Hossain
Diseases is an unusual circumstance that affects single or more parts of a human’s body. Because of lifestyle and patrimonial, different kinds of disease are increasing day by day. Among all those diseases, heart disease turns out to be the most common disease and the impact of this ailment is dange...
Ariel Roguin, Juerg Schwitter, Christian Vahlhaus, Massimo Lombardi et al.
Magnetic resonance (MR) imaging has unparalleled soft-tissue imaging capabilities. The presence of devices such as pacemakers and implantable cardioverter-defibrillators (ICDs), however, was historically considered a contraindication to MR imaging. We summarize the potential hazards of the device-MR...
Ole Fröbert, Matthias Götberg, David Erlinge, Zubair Akhtar et al.
Background: Observational and small, randomized studies suggest that influenza vaccine may reduce future cardiovascular events in patients with cardiovascular disease. Methods: We conducted an investigator-initiated, randomized, double-blind trial to compare inactivated influenza vaccine with saline...