Md. Sahab Uddin, Md. Tanvir Kabir, Devesh Tewari, Abdullah Al Mamun et al.
Amyloid beta (Aβ) is an intricate molecule that interacts with several biomolecules and/or produces insoluble assemblies and eventually the nonphysiological depositions of its alternate with normal neuronal conditions leading to Alzheimer's disease (AD). Aβ is formed through the proteolytic cleavage...
Md. Asaduzzaman, Md. Josim Uddin, M.A. Kader, AHM Khurshid Alam et al.
BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disorder clinically characterized by loss of memory and cognition. The effective therapeutic options for AD are limited and thus there is a demand for new drugs. Aegle marmelos (Linn.) (A. marmelos) leaves have been used in trad...
Md. Sahab Uddin, Md. Tanvir Kabir, Philippe Jeandet, Bijo Mathew et al.
Alzheimer’s disease (AD) is the most common cause of dementia among older people, and the prevalence of this disease is estimated to rise quickly in the upcoming years. Unfortunately, almost all of the drug candidates tested for AD until now have failed to exhibit any efficacy. Henceforth, there is ...
Nurshad Ali, Md. Ashraful Hoque, Abedul Haque, Kazi Abdus Salam et al.
BACKGROUND: Arsenic is a potent pollutant that has caused an environmental catastrophe in certain parts of the world including Bangladesh where millions of people are presently at risk due to drinking water contaminated by arsenic. Chronic arsenic exposure has been scientifically shown as a cause fo...
Md. Sahab Uddin, Abdullah Al Mamun, Md. Saddam Hossain, Muhammad Ashaduzzaman et al.
Nature is the best source of complementary and alternative medicine. The plant Phyllanthus acidus (PA) L. has been used traditionally in pain, inflammatory and oxidative stress related disorders. In this consequence, methanolic extract of PA (MEPA) was selected to explore the ability of this plant t...
Asif Abdullah, Partha Biswas, Md. Sahabuddin, Afiya Mubasharah et al.
Diabetes mellitus is a chronic hormonal and metabolic disorder in which our body cannot generate necessary insulin or does not act in response to it, accordingly, ensuing in discordantly high blood sugar (glucose) levels. Diabetes mellitus can lead to systemic dysfunction in the multiorgan system, i...
Ramya Ranganathan, Shaila Haque, Kayesha Coley, Stephanie Shepheard et al.
Amyotrophic lateral sclerosis and frontotemporal dementia are two progressive, adult onset neurodegenerative diseases, caused by the cell death of motor neurons in the motor cortex and spinal cord and cortical neurons in the frontal and temporal lobes respectively. Whilst these have previously appea...
S.M. Rafiquzzaman, Eun Young Kim, Jong Min Lee, Md. Mohibbullah et al.
Undaria pinnatifida Harvey is an edible brown macroalga that has several pharmacologically important traits. We previously described the purification and chemical composition of a glycoprotein from U. pinnatifida (UPGP) and characterized its antioxidant and DNA protection activities. In the present ...
Raju Dash, Talha Bin Emran, Mir Muhammad Nasir Uddin, Ashekul Islam et al.
Alzheimer׳s disease (AD) is one of the most common dementias showing slow progressive cognitive decline. Progression of intracerebral accumulation of beta amyloid (Aβ) peptides by the action of amyloid binding alcohol dehydrogenase (ABAD), a mitochondrial enzyme and β-site amyloid precursor protein ...
Bijo Mathew, Seung Cheol Baek, Della Grace Thomas Parambi, Jae P. Lee et al.
Abstract Two series of fluorinated chalcones containing morpholine and imidazole‐based compounds ( f1–f8 ) were synthesized and evaluated for recombinant human monoamine oxidase (MAO)‐A and ‐B as well as acetylcholinesterase inhibitory activities. Our results indicate that morpholine containing chal...
Md. Tanvir Kabir, Md. Sahab Uddin, Philippe Jeandet, Talha Bin Emran et al.
Alzheimer's disease (AD) is a devastating neurodegenerative disease and the most common cause of dementia. It has been confirmed that the pathological processes that intervene in AD development are linked with oxidative damage to neurons, neuroinflammation, tau phosphorylation, amyloid beta (Aβ) agg...
Bijo Mathew, Della Grace Thomas Parambi, Vishnu Sankar Sivasankarapillai, Md. Sahab Uddin et al.
The development of chalcone-based compounds for CNS disorders has been explored by many research groups. Chalcones are being considered as a potent organic scaffold with widespread applications in the field of drug discovery and medicinal chemistry. The planar or semi-planar geometry of chalcones wi...
Nimra Javaid, Muhammad Ajmal Shah, Azhar Rasul, Zunera Chauhdary et al.
Neurodegeneration is a multifactorial process involved the different cytotoxic pathways that lead to neuronal cell death. Alzheimer’s disease (AD) is a persistent neurodegenerative disorder that normally has a steady onset and gradually worsens. Neuropathology, AD is characterized by the presence of...
Abdullah Al Mamun, Md. Sahab Uddin, Md. Fahim Bin Bashar, Sonia Zaman et al.
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that causes chronic cognitive dysfunction. Most of the AD cases are late onset, and the apolipoprotein E ( APOE ) isoform is a key genetic risk factor. The APOE gene has 3 key alleles in humans including APOE2 , APOE3 , and APOE4 . ...
Teuku Rizky Noviandy, Aga Maulana, Talha Bin Emran, Ghazi Mauer Idroes et al.
This study focuses on the development of a machine learning ensemble approach for the classification of Beta-Secretase 1 (BACE1) inhibitors in Quantitative Structure-Activity Relationship (QSAR) analysis. BACE1 is an enzyme linked to the production of amyloid beta peptide, a significant component of...