Walter Vincken, J.A. van Noord, A.P.M. Greefhorst, Th.A. Bantje et al.
Tiotropium, a novel once-daily inhaled anticholinergic, has been shown to improve lung function over a 24-h period. In order to extend these findings, health-outcomes were evaluated over 1 yr in chronic obstructive pulmonary disease (COPD) patients. Spirometric results, peak expiratory flow rate (PE...
Ana Maria B. Menezes, María Montes de, Rogelio Pérez‐Padilla, Gilbert Nadeau et al.
Background Several COPD phenotypes have been described; the COPD-asthma overlap is one of the most recognized. The aim of this study was to evaluate the prevalence of three subgroups (asthma, COPD, and COPD-asthma overlap) in the Latin American Project for the Investigation of Obstructive Lung Disea...
Mario Kinsella, Néstor L. Müller, Raja T. Abboud, Nancy Morrison et al.
We used a CT program "density mask" outlining areas with attenuation values less than -910 HU, to indicate areas of emphysema on a chest CT and to provide an overall percentage of lung involvement by emphysema. The "density mask" quantitation of emphysema was previously shown to correlate well with ...
MyLinh Duong, Shofiqul Islam, Sumathy Rangarajan, Darryl P. Leong et al.
BACKGROUND: ) impairment and mortality, incident cardiovascular disease, and respiratory hospitalisations are unclear, and how these associations might vary across populations is unknown. METHODS: % <-2 SDs [ie, clinically abnormal range]). Follow-up was done every 3 years to collect information on ...
Denis E. O’Donnell, Jordan A. Guenette, François Maltais, Katherine A. Webb
Background To better understand the interrelationships among disease severity, inspiratory capacity (IC), breathing pattern, and dyspnea, we studied responses to symptom-limited cycle exercise in a large cohort with COPD. Methods Analysis was conducted on data from two previously published replicate...
Jean Bousquet, Antonio Addis, Ian M. Adcock, Ioana Agache et al.
The objective of Integrated Care Pathways for Airway Diseases (AIRWAYS-ICPs) is to launch a collaboration to develop multi-sectoral care pathways for chronic respiratory diseases in European countries and regions. AIRWAYS-ICPs has strategic relevance to the European Union Health Strategy and will ad...
Mike Thomas, Robert K McKinley, Sarah Mellor, G Watkin et al.
BACKGROUND: The effect of breathing modification techniques on asthma symptoms and objective disease control is uncertain. METHODS: A prospective, parallel group, single-blind, randomised controlled trial comparing breathing training with asthma education (to control for non-specific effects of clin...
Philip H. Quanjer, Sanja Stanojevic, Janet Stocks, Graham L. Hall et al.
In children, the ratio of forced expiratory volume in 1 s (FEV₁) to forced vital capacity (FVC) is reportedly constant or falls linearly with age, whereas the ratio of residual volume (RV) to total lung capacity (TLC) remains constant. This seems counter-intuitive given the changes in airway propert...
Jordan A. Guenette, Roberto C. Chin, Sicheng Cheng, Paolo B. Dominelli et al.
The purpose of this study was to determine if a dissociation existed between respiratory drive, as estimated by diaphragmatic electromyography (EMGdi), and its pressure-generating capacity during exercise in mild chronic obstructive pulmonary disease (COPD) and whether this, if present, had negative...
the ARIA Study Group, J. Jean Bousquet, the MASK Study Group, Holger J. Schünemann et al.
BACKGROUND: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizati...
June Nunn, Naznin Bhimji, Janet Darby- Shire, K M Citron et al.
A survey of all tuberculosis notifications in England and Wales for a six-month period showed that 70% of 3732 newly notified, previously untreated patients had respiratory disease only, 23% had non-respiratory disease only, and 7% had both. Fifty-seven per cent of patients were of white and 35% wer...
Matthew R. Grigsby, Trishul Siddharthan, Muhammad Chowdhury, Ali Tanweer Siddiquee et al.
BACKGROUND: Socioeconomic status (SES) is a strong social determinant of health. There remains a limited understanding of the association between SES and COPD prevalence among low- and middle-income countries where the majority of COPD-related morbidity and mortality occurs. We examined the associat...
Isabelle Couillin, Virginie Vasseur, Sabine Charron, Paméla Gasse et al.
Lung emphysema and fibrosis are severe complications of chronic obstructive pulmonary disease, and uncontrolled protease activation may be involved in the pathogenesis. Using experimental elastase-induced acute inflammation, we demonstrate here that inflammation and development of emphysema is IL-1R...
Thomas P. Olson, Michael J. Joyner, Niki M. Dietz, John H. Eisenach et al.
Heart failure (HF) patients have a reduced cardiac reserve and increased work of breathing. Increased locomotor muscle blood flow demand may result in competition between respiratory and locomotor vascular beds. We hypothesized that HF patients would demonstrate improved locomotor blood flow with re...
Olaf Holz, Rudolf A. Jörres, PETRA TIMM, Marion Mücke et al.
To study whether the individual inflammatory response to ozone was reproducible, dose-dependent, and time-dependent, we performed two exposures to 250 ppb ozone, one to 125 ppb and one to filtered air, each for 3 h of intermittent exercise and separated by at least 1 wk. Twenty-one healthy and 15 as...