Nicola Longo, Cristina Amat Di San Filippo, Marzia Pasquali
Carnitine plays an essential role in the transfer of long-chain fatty acids across the inner mitochondrial membrane. This transfer requires enzymes and transporters that accumulate carnitine within the cell (OCTN2 carnitine transporter), conjugate it with long chain fatty acids (carnitine palmitoyl ...
Elizabeta Zaplatić, Mohammed Hussen Bule, Syed Zahid Ali Shah, Md. Sahab Uddin et al.
Quercetin belongs to the flavonoids family, which is present in most of the plants including fruits, vegetables, green tea and even in red wine having antioxidant activities. It is available as a food supplement in the market and has physiological health effects. Quercetin has anti-inflammatory, ant...
Amarjot Kaur Grewal, Thakur Gurjeet Singh, Deepak Sharma, Veerta Sharma et al.
Neurodegenerative diseases (NDDs) are the primary cause of disabilities in the elderly people. Growing evidence indicates that oxidative stress, mitochondrial dysfunction, neuroinflammation and apoptosis are associated with aging and the basis of most neurodegenerative disorders. Quercetin is a flav...
Alan W. Stitt
The pathogenesis of diabetic retinopathy is multifactorial, and a range of hyperglycemia-linked pathways have been implicated in the initiation and progression of this condition. All cells in the retina are affected by the diabetic milieu, and in view of such disease and tissue complexity, it is unl...
Md. Abdus Salam, Md. Yusuf Al-Amin, Jogendra Singh Pawar, Naseem Akhter et al.
Antimicrobial susceptibility testing is an essential task for selecting appropriate antimicrobial agents to treat infectious diseases. Constant evolution has been observed in methods used in the diagnostic microbiology laboratories. Disc diffusion or broth microdilution are classical and conventiona...
Gary L. Hedlund, Nicola Longo, Marzia Pasquali
Glutaric acidemias comprise different disorders resulting in an increased urinary excretion of glutaric acid. Glutaric acidemia type 1 (GA-1) is an autosomal recessive disorder of lysine, hydroxylysine, and tryptophan metabolism caused by deficiency of glutaryl-CoA dehydrogenase. It results in the a...
Rejina Afrin, Somasundaram Arumugam, Md. Azizur Rahman, Mir Imam Ibne Wahed et al.
Curcumin, a phenolic compound, has a wide spectrum of therapeutic effects such as antitumor, anti-inflammatory, anti-cancer and so on. The study aimed to investigate the underlying mechanisms of curcumin to protect liver damage and progression of non-alcoholic steatohepatitis (NASH) in a novel NASH-...
Ajit Ghosh, Hemant R. Kushwaha, Mohammad Rokebul Hasan, Ashwani Pareek et al.
Glyoxalase pathway, comprising glyoxalase I (GLY I) and glyoxalase II (GLY II) enzymes, is the major pathway for detoxification of methylglyoxal (MG) into D-lactate involving reduced glutathione (GSH). However, in bacteria, glyoxalase III (GLY III) with DJ-1/PfpI domain(s) can do the same conversion...
Amanda J. Driscoll, Maria Deloria Knoll, Laura L. Hammitt, Henry C. Baggett et al.
BACKGROUND.: Antibiotic exposure and specimen volume are known to affect pathogen detection by culture. Here we assess their effects on bacterial pathogen detection by both culture and polymerase chain reaction (PCR) in children. METHODS.: PERCH (Pneumonia Etiology Research for Child Health) is a ca...
Ajit Ghosh, Tahmina Islam
BACKGROUND: Glyoxalase pathway consists of two enzymes, glyoxalase I (GLYI) and glyoxalase II (GLYII) which detoxifies a highly cytotoxic metabolite methylglyoxal (MG) to its non-toxic form. MG may form advanced glycation end products with various cellular macro-molecules such as proteins, DNA and R...
Charles H. Rodeck, Marcus Pembrey, A. D. Patrick, C Tzannatos et al.
Dilruba Ahmed, Md Ausrafuggaman Nahid, Abdullah Bashar Sami, Farhana Halim et al.
Bloodstream infections due to bacterial pathogens are a major cause of morbidity and mortality in Bangladesh and other developing countries. In these countries, most patients are treated empirically based on their clinical symptoms. Therefore, up to date etiological data for major pathogens causing ...
Afshan N. Malik, Rojeen Shahni, Muhammad Usman Iqbal
We report that mitochondrial DNA (MtDNA) copy numbers are increased in peripheral blood of patients with diabetic nephropathy (DN). Using qPCR for quantitation, we found a 2-4-fold significant increase (p<0.05) in the mean MtDNA values in DN patients vs. healthy controls and diabetics without nephro...
Urh Grošelj, Mojca Žerjav Tanšek, Andraž Šmon, Natalija Angelkova et al.
The aim of our study was to assess the current state of newborn screening (NBS) in the region of southeastern Europe, as an example of a developing region, focusing also on future plans. Responses were obtained from 11 countries. Phenylketonuria screening was not introduced in four of 11 countries, ...
Mojca Žerjav Tanšek, Urh Grošelj, Natalija Angelkova, D Anton et al.
BACKGROUND: We aimed to assess the current state of PKU screening and management in the region of southeastern Europe. METHODS: A survey was performed involving all identified professionals responsible for the PKU management in the 11 countries from South-Eastern region of Europe (Albania, Bulgaria,...