Mustafa Mahfuz, Subhasish Das, Ramendra Nath Mazumder, Mujibur Rahman et al.
INTRODUCTION: Environmental enteric dysfunction (EED) is a subacute inflammatory condition of the small intestinal mucosa with unclear aetiology that may account for more than 40% of all cases of stunting. Currently, there are no universally accepted protocols for the diagnosis, treatment and ultima...
William Manzanares, Rupinder Dhaliwal, Brian Jurewitsch, Renee D. Stapleton et al.
PurposeParenteral lipid emulsions (LEs) are commonly rich in long-chain triglycerides derived from soybean oil (SO). SO-containing emulsions may promote systemic inflammation and therefore may adversely affect clinical outcomes. We hypothesized that alternative oil-based LEs (SO-sparing strategies) ...
Rebecca K. Campbell, Kerry Schulze, Saijuddin Shaikh, Sucheta Mehra et al.
OBJECTIVES: Environmental enteric dysfunction (EED) may inhibit growth and development in low- and middle-income countries, but available assessment methodologies limit its study. In rural Bangladesh, we measured EED using the widely used lactulose mannitol ratio (L:M) test and a panel of intestinal...
Rubhana Raqib, S. M. Shahjahan Mia, Firdausi Qadri, Tanfis I. Alam et al.
An array of pro- and anti-inflammatory mediators of the innate immune system was analyzed in stool, urine, and rectal mucosa samples from adults and children with shigellosis to better understand their role in recovery from and in the immunopathogenesis of the disease. Increased concentrations of la...
A R Samadi, M A Wahed, M R Islam, S M Ahmed
A total of 1330 children under 3 years of age who during 1979 had been admitted to the general ward of ICDDR,B Health Complex for diarrhoea with complications were studied retrospectively for the relation between types of dehydration, age, and nutritional state. Of the 1330 children, 276 (20.8%) wer...
Nur Alam, Sufia Islam, Samima Sattar, Shirajum Monira et al.
OBJECTIVES: Assess the safety of rapid intravenous rehydration of severely malnourished children and compare the efficacy of 3 formulations of oral rehydration salts solutions. PATIENTS AND METHODS: A group of 175 severely malnourished children of either sex (weight/length <70% of National Center fo...
F. C. Patra, David A. Sack, Asma Islam, A. N. Alam et al.
OBJECTIVE: To determine whether adding L-alanine to the glucose based oral rehydration solution recommended by the World Health Organisation would improve its efficacy in treating acute diarrhoea. DESIGN: Randomised double blind controlled trial of oral rehydration solution containing L-alanine and ...
Mohammod Jobayer Chisti, Mohammed Abdus Salam, Pradip Kumar Bardhan, Abu Syed Golam Faruque et al.
BACKGROUND: Appropriate intervention is critical in reducing deaths among under-five, severe acutely malnourished (SAM) children with danger signs of severe pneumonia; however, there is paucity of data on outcome of World Health Organisation (WHO) recommended interventions of SAM children with sever...
Mohammod Jobayer Chisti, Mark AC Pietroni, Jonathan H. Smith, Pradip Kumar Bardhan et al.
AIM: To evaluate the clinical and laboratory predictors of death in hospitalized under-five children with diarrhoea. METHODS: This is a prospective cohort study carried out in the Special Care Ward (SCW) of the Dhaka Hospital of the International Centre for Diarrhoeal Disease Research, Bangladesh (I...
Md Iqbal Hossain, Baitun Nahar, Jena Hamadani, Tahmeed Ahmed et al.
OBJECTIVE: Lactulose/mannitol (L/M) intestinal permeability tests were completed to compare the intestinal function of severely underweight children recovering from diarrhea and other illnesses and of nonmalnourished children from the same communities, and to evaluate the effects of food supplementa...
Adam C. Levine, Justin Glavis‐Bloom, Payal Modi, Sabiha Nasrin et al.
BACKGROUND: Dehydration due to diarrhoea is a leading cause of child death worldwide, yet no clinical tools for assessing dehydration have been validated in resource-limited settings. The Dehydration: Assessing Kids Accurately (DHAKA) score was derived for assessing dehydration in children with diar...
Mohammod Jobayer Chisti, Mohammed Abdus Salam, Hasan Ashraf, A. S. G. Faruque et al.
BACKGROUND: Risks of death are high when children with pneumonia also have severe acute malnutrition (SAM) as a co-morbidity. However, there is limited published information on risk factors of death from pneumonia in SAM children. We evaluated clinically identifiable factors associated with death in...
Kathryn G. Dewey, Charles D. Arnold, K. Ryan Wessells, Elizabeth L. Prado et al.
BACKGROUND: Meta-analyses show that small-quantity lipid-based nutrient supplements (SQ-LNSs) reduce child wasting and stunting. There is little information regarding effects on severe wasting or stunting. OBJECTIVES: We aimed to identify the effect of SQ-LNSs on prevalence of severe wasting (weight...
Audrie Lin, Shahjahan Ali, Benjamin F. Arnold, Md Ziaur Rahman et al.
BACKGROUND: We hypothesized that drinking water, sanitation, handwashing (WSH), and nutritional interventions would improve environmental enteric dysfunction (EED), a potential contributor to stunting. METHODS: Within a subsample of a cluster-randomized, controlled trial in rural Bangladesh, we enro...
Richard J. Maude, Gofranul Hoque, Mahtab Uddin Hasan, Abu Sayeed et al.
BACKGROUND: Early start of enteral feeding is an established treatment strategy in intubated patients in intensive care since it reduces invasive bacterial infections and length of hospital stay. There is equipoise whether early enteral feeding is also beneficial in non-intubated patients with cereb...