Mandy Ng, Douglas F. Levinson, Stephen V. Faraone, Brian K. Suarez et al.
A genome scan meta-a nalysis (GSMA) was carried out on 32 independent genome-wide linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected with schizophrenia (SCZ) or related disorders. The primary GSMA divided the autosomes into 120 bins, rank-ordered the bins within ea...
Patrick Munk, Christian Brinch, Frederik Duus Møller, Thomas Nordahl Petersen et al.
Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 7...
Trina Ekawati Tallei, Sefren Geiner Tumilaar, Nurdjannah Jane Niode, Fatimawali Fatimawali et al.
Since the outbreak of the COVID-19 (coronavirus disease 19) pandemic, researchers have been trying to investigate several active compounds found in plants that have the potential to inhibit the proliferation of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). The present study aimed to ...
Joris Deelen, Marian Beekman, Hae‐Won Uh, Linda Broer et al.
The genetic contribution to the variation in human lifespan is ∼ 25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We performed a genome-wide association meta-analysis of 7729 long-lived individuals of European descent...
Alexandre F. Aissa, Abul Bashar Mir Md. Khademul Islam, Majd Ariss, Cammille C. Go et al.
Tyrosine kinase inhibitors were found to be clinically effective for treatment of patients with certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases. However, the duration of clinical response is often limited, and patients ultimately develop drug resistance. Here, we u...
Shawna McCallin, Shafiqul Alam Sarker, Caroline Barretto, Shamima Sultana et al.
Phage therapy has a long tradition in Eastern Europe, where preparations are comprised of complex phage cocktails whose compositions have not been described. We investigated the composition of a phage cocktail from the Russian pharmaceutical company Microgen targeting Escherichia coli/Proteus infect...
Jason Derks, Andrew Leduc, Georg Wallmann, R. Gray Huffman et al.
Proteomics of small sample sizes using data-independent acquisition methods achieves higher throughput with multiplexing. Current mass spectrometry methods enable high-throughput proteomics of large sample amounts, but proteomics of low sample amounts remains limited in depth and throughput. To incr...
Georgia Drakakaki, Wilhelmina van de Ven, Songqin Pan, Yansong Miao et al.
The endomembrane system is a complex and dynamic intracellular trafficking network. It is very challenging to track individual vesicles and their cargos in real time; however, affinity purification allows vesicles to be isolated in their natural state so that their constituent proteins can be identi...
Aleksandra A. Petelski, Edward Emmott, Andrew Leduc, R. Gray Huffman et al.
Many biological systems are composed of diverse single cells. This diversity necessitates functional and molecular single-cell analysis. Single-cell protein analysis has long relied on affinity reagents, but emerging mass-spectrometry methods (either label-free or multiplexed) have enabled quantifyi...
Rajib Roychowdhury, Soumya Prakash Das, Amber Gupta, Parul Parihar et al.
The present day's ongoing global warming and climate change adversely affect plants through imposing environmental (abiotic) stresses and disease pressure. The major abiotic factors such as drought, heat, cold, salinity, etc., hamper a plant's innate growth and development, resulting in reduced yiel...
Effi Haque, Hiroaki Taniguchi, Md Mahmudul Hassan, Pankaj Bhowmik et al.
The world population is expected to increase from 7.3 to 9.7 billion by 2050. Pest outbreak and increased abiotic stresses due to climate change pose a high risk to tropical crop production. Although conventional breeding techniques have significantly increased crop production and yield, new approac...
Richard J. Abdill, Elizabeth M. Adamowicz, Ran Blekhman
The importance of sampling from globally representative populations has been well established in human genomics. In human microbiome research, however, we lack a full understanding of the global distribution of sampling in research studies. This information is crucial to better understand global pat...
Rabbee G. Mahmudunnabi, Fatema Zerin Farhana, Navid Kashaninejad, Shakhawat H. Firoz et al.
In recent years, a new group of nanomaterials named nanozymes that exhibit enzyme-mimicking catalytic activity has emerged as a promising alternative to natural enzymes. Nanozymes can address some of the intrinsic limitations of natural enzymes such as high cost, low stability, difficulty in storage...
Md. Fakruddin, KhanjadaShahnewaj Bin Mannan, Abhijit Chowdhury, ReazMohammad Mazumdar et al.
Nucleic acid amplification is a valuable molecular tool not only in basic research but also in application oriented fields, such as clinical medicine development, infectious diseases diagnosis, gene cloning and industrial quality control. A comperehensive review of the literature on the principles, ...
Huimin Wang, Chunxiao Li, Xiaoqing Liu, Xiang Zhou et al.
A rationally and modularly engineered two-layered CHA–HCR circuit was constructed for amplified biosensing and bioimaging with high performance.