Claire Wainwright, J.S. Elborn, Bonnie W. Ramsey, Gautham Marigowda et al.
BACKGROUND: Combination treatment with the cystic fibrosis transmembrane conductance regulator (CFTR) modulators tezacaftor (VX-661) and ivacaftor (VX-770) was designed to target the underlying cause of disease in patients with cystic fibrosis. METHODS: through week 24 (calculated as a percentage) w...
You Li, Rachel M Reeves, Xin Wang, Quique Bassat et al.
BACKGROUND: Influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus are the most common viruses associated with acute lower respiratory infections in young children (<5 years) and older people (≥65 years). A global report of the monthly activity of these viruses is nee...
Gail Deutsch, Lisa R. Young, Robin R. Deterding, Leland L. Fan et al.
RATIONALE: Considerable confusion exists regarding nomenclature, classification, and management of pediatric diffuse lung diseases due to the relative rarity and differences in the spectrum of disease between adults and young children. OBJECTIVES: A multidisciplinary working group was formed to: (1)...
John P. Clancy, Lieven Dupont, Michael W. Konstan, Joanne Billings et al.
RATIONALE: Arikace is a liposomal amikacin preparation for aerosol delivery with potent Pseudomonas aeruginosa killing and prolonged lung deposition. OBJECTIVES: To examine the safety and efficacy of 28 days of once-daily Arikace in cystic fibrosis (CF) patients chronically infected with P aeruginos...
Alan Haynes, Arie Manangan, Marika K. Iwane, Katharine Sturm‐Ramirez et al.
BACKGROUND: Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in young children globally, with the highest burden in low- and middle-income countries where the association between RSV activity and climate remains unclear. METHODS: Monthly laboratory-confirm...
Melissa M. Higdon, Tham Le, Katherine L. O’Brien, David R. Murdoch et al.
BACKGROUND.: Lack of a gold standard for identifying bacterial and viral etiologies of pneumonia has limited evaluation of C-reactive protein (CRP) for identifying bacterial pneumonia. We evaluated the sensitivity and specificity of CRP for identifying bacterial vs respiratory syncytial virus (RSV) ...
Paul Buchanan, Robert K. Ernst, J.S. Elborn, Bettina Schock
CF (cystic fibrosis) is a severe autosomal recessive disease most common in Northwest European populations. Underlying mutations in the CFTR (CF transmembrane conductance regulator) gene cause deregulation of ion transport and subsequent dehydration of the airway surface liquid, producing a viscous ...
Dongqi Wang, Yueyun Li, Helen Cope, Xiaoxiao Li et al.
Polyphosphate (polyP) accumulating organisms (PAOs) are the key agent to perform enhanced biological phosphorus removal (EBPR) activity, and intracellular polyP plays a key role in this process. Potential associations between EBPR performance and the polyP structure have been suggested, but are yet ...
Rémi Villenave, Lindsay Broadbent, Isobel Douglas, Jeremy Lyons et al.
UNLABELLED: Airway epithelium is the primary target of many respiratory viruses. However, virus induction and antagonism of host responses by human airway epithelium remains poorly understood. To address this, we developed a model of respiratory syncytial virus (RSV) infection based on well-differen...
Judy Bradley, Steven W. Blume, Maria‐Magdalena Balp, D. Honeybourne et al.
The aim of our study was to discover the health status and healthcare utilisation associated with pulmonary exacerbations in cystic fibrosis (CF) and chronic Pseudomonas aeruginosa infection. Patients with CF from five UK CF centres attended two visits, 8-12 weeks apart. They were classified at visi...
Aislinn Cook, Laura Ferreras, B. Adhisivam, Daynia Ballot et al.
Neonatal invasive candidiasis (NIC) has significant morbidity and mortality. Reports have shown a different profile of those neonates affected with NIC and of fluconazole-resistant Candida spp. isolates in low- and middle-income countries (LMICs) compared to high-income countries (HICs). We describe...
Amanda J. Driscoll, Ruth A. Karron, Susan C. Morpeth, Niranjan Bhat et al.
The Pneumonia Etiology Research for Child Health study was conducted across 7 diverse research sites and relied on standardized clinical and laboratory methods for the accurate and meaningful interpretation of pneumonia etiology data. Blood, respiratory specimens, and urine were collected from child...
Dianna M. Blau, Vicky L. Baillie, Toyah Els, Sana Mahtab et al.
BACKGROUND: Lower respiratory tract infections are a leading cause of death in young children, but few studies have collected the specimens needed to define the role of specific causes. The Child Health and Mortality Prevention Surveillance (CHAMPS) platform aims to investigate causes of death in ch...
Luis Máiz, Rosa Girón, Casilda Olveira, E.C. Quintana et al.
INTRODUCTION: Inhaled antibiotics are probably the safest and most effective therapy for Pseudomonas aeruginosa chronic lung infection in cystic fibrosis (CF) patients. AREAS COVERED: To summarise the available evidence, a systematic review of the three currently available inhaled antibiotics (aztre...
Tülay Güran, Refika Ersu, Bülent Karadağ, İhsan Akpınar et al.
To study clinical, radiological and laboratory features of children with non-cystic fibrosis (non-CF) bronchiectasis (BE) and the association between symptom scores, spirometry, high-resolution computed tomography (HRCT) findings and inflammatory markers in induced sputum in these children. Twenty-s...