Nicola Longo, Cristina Amat Di San Filippo, Marzia Pasquali
Carnitine plays an essential role in the transfer of long-chain fatty acids across the inner mitochondrial membrane. This transfer requires enzymes and transporters that accumulate carnitine within the cell (OCTN2 carnitine transporter), conjugate it with long chain fatty acids (carnitine palmitoyl ...
Jiayu Ma, Xiangshu Piao, Shad Mahfuz, Shenfei Long et al.
The mammalian gut is inhabited by a massive and complicated microbial community, in which the host achieves a stable symbiotic environment through the interdependence, coordination, reciprocal constraints and participation in an immune response. The interaction between the host gut and the microbiot...
Shoumen Lasker, Md Mizanur Rahman, Faisal Parvez, Mushfera Zamila et al.
The main objective of this experiment was to determine the effects of yogurt supplementation on fat deposition, oxidative stress, inflammation and fibrosis in the liver of rats with high-fat (HF) diet-induced obesity. Male Wistar rats were used in this study and were separated into the following fou...
Md. Mominur Rahman, Fahadul Islam, Md. Harun- Or-Rashid, Abdullah Al Mamun et al.
In the last two decades, considerable interest has been shown in understanding the development of the gut microbiota and its internal and external effects on the intestine, as well as the risk factors for cardiovascular diseases (CVDs) such as metabolic syndrome. The intestinal microbiota plays a pi...
Chayon Goswami, Yusaku Iwasaki, Toshihiko Yada
Fermentable carbohydrates including dietary fibers and resistant starch produce short-chain fatty acids (SCFAs), including acetate, propionate and butyrate, through microbial fermentation in the intestine of rodents and humans. Consumption of fermentable carbohydrate and SCFAs suppress food intake, ...
Neelendu Dey, Vitas E. Wagner, Laura V. Blanton, Jiye Cheng et al.
To understand how different diets, the consumers’ gut microbiota and the enteric nervous system (ENS) interact to regulate gut motility, we developed a gnotobiotic mouse model that mimics short-term dietary changes that happen when humans are traveling to places with different culinary traditions. S...
Md Mahdi Hasan‐Olive, Knut H. Lauritzen, Mohammad Ali, Lene Juel Rasmussen et al.
A ketogenic diet (KD; high-fat, low-carbohydrate) can benefit refractory epilepsy, but underlying mechanisms are unknown. We used mice inducibly expressing a mutated form of the mitochondrial DNA repair enzyme UNG1 (mutUNG1) to cause progressive mitochondrial dysfunction selectively in forebrain neu...
Kwang Wei Tham, Rohana Abdul Ghani, Sioksoan C. Cua, Chaicharn Deerochanawong et al.
Obesity is a chronic disease in which the abnormal or excessive accumulation of body fat leads to impaired health and increased risk of mortality and chronic health complications. Prevalence of obesity is rising rapidly in South and Southeast Asia, with potentially serious consequences for local eco...
Md Monirujjaman, Afroza Ferdouse
Branch chain amino acids (BCAAs) have unique properties with diverse physiological and metabolic roles. They have functions other than simple nutrition. Different diseases including metabolic disease lead to protein loss, especially muscle protein. Supplementation of BCAAs promotes protein synthesis...
Michael J. Barratt, Sharika Nuzhat, Kazi Ahsan, Steven A. Frese et al.
Disrupted development of the gut microbiota is a contributing cause of childhood malnutrition. Bifidobacterium longum subspecies infantis is a prominent early colonizer of the infant gut that consumes human milk oligosaccharides (HMOs). We found that the absolute abundance of Bifidobacterium infanti...
Mohamed Derouich, Abdesslam Boutayeb
Regular physical activity is indicated either to prevent and delay the onset of non-insulin-dependent diabetes or to assure a good control of diabetes by increasing insulin sensitivity and ameliorating the metabolism of glucose disappearance. Many studies and experiments have dealt with this subject...
Xufen Zeng, Krista A Varady, Xiangdong Wang, Giovanni Targher et al.
Metabolic dysfunction-associated fatty liver disease (MAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD), has become the leading cause of chronic liver disease worldwide. Optimal dietary intervention strategies for MAFLD are not standardized. This study aimed to achieve conse...
Michael L. Bennish, Abul Kalam Azad, Omar Rahman, Rodney E. Phillips
To determine the frequency and outcome of hypoglycemia during diarrhea in childhood, we screened 2003 consecutive patients less than 15 years of age who were admitted to a diarrhea treatment center in Dhaka, Bangladesh. Hypoglycemia, defined as a blood glucose concentration less than 2.2 mmol per li...
Ryan T. Hurt, Stephen A. McClave, Robert G. Martindale, Juan B. Ochoa Gautier et al.
The International Protein Summit in 2016 brought experts in clinical nutrition and protein metabolism together from around the globe to determine the impact of high-dose protein administration on clinical outcomes and address barriers to its delivery in the critically ill patient. It has been sugges...
Yi Zhao, De-Xing Ma, Hongguang Wang, Muzi Li et al.
Di(2-ethylhexyl) phthalate (DEHP) is a widespread pollutant that badly affects animals and human health. Lycopene (LYC) has been used as a dietary supplement that has effective antioxidant and antiobesity functions. The present goal was to understand the molecular mechanisms of LYC preventing DEHP-i...