Nicola Martinelli, Domenico Girelli, Giovanni Malerba, Patrizia Guarini et al.
Background The delta-5 and delta-6 desaturases, encoded by FADS1 and FADS2 genes, are key enzymes in polyunsaturated fatty acid (PUFA) metabolism that catalyze the conversion of linoleic acid (LA) into arachidonic acid (AA) and that of alpha-linolenic acid (ALA) into eicosapentaenoic acid (EPA). Sin...
Mirja Kaizer Ahmmed, Fatema Ahmmed, Hong Tian, Alan Carne et al.
For several decades, there has been considerable interest in marine-derived long chain n-3 fatty acids (n-3 LCPUFAs) due to their outstanding health benefits. n-3 LCPUFAs can be found in nature either in triglycerides (TAGs) or in phospholipid (PL) form. From brain health point of view, PL n-3 is mo...
Takafumi Nagatomo, Mamunur Rashid, Habib Abul Muntasir, Tadazumi Komiyama
The serotonin (5-hydroxytryptamine, 5-HT) receptors have conventionally been divided into seven subfamilies, most of which have several subtypes. Among them, 5-HT(2A) receptor is associated with the contraction of vascular smooth muscle, platelet aggregation and thrombus formation and coronary arter...
Michio Hashimoto, Masanori Katakura, Yoko Tanabe, Abdullah Al Mamun et al.
We investigated whether a highly purified eicosapentaenoic acid (EPA) and a concentrated n-3 fatty acid formulation (prescription TAK-085) containing EPA and docosahexaenoic acid (DHA) ethyl ester could improve the learning ability of aged rats and whether this specific outcome had any relation with...
Mohammad Safiqul Islam, Maizbha Uddin Ahmed, Muhammad Shahdaat Bin Sayeed, Abdullah Al Maruf et al.
Background CYP1A1, CYP2A6 and CHRNA5 are biologically plausible genes as risk factors for lung cancer but no studies have been reported in the Bangladeshi population. Methods We conducted this study to determine the prevalence and role of CYP1A1, CYP2A6 and CHRNA5 polymorphisms together with tobacco...
Md. Abdur Rahman Ripon, Dipty Rani Bhowmik, Mohammad Tohidul Amin, Mohammad Salim Hossain
The World Health Organization has described the 2019 Coronavirus disease caused by an influenza-like virus called SARS-CoV-2 as a pandemic. Millions of people worldwide are already infected by this virus, and severe infection causes hyper inflammation, thus disrupting lung function, exacerbating bre...
Mohammad Sharifur Rahman
Prostaglandins (PGs) belong to the group lipid mediators and can act as local hormones. They contain 20 carbon atoms, including a 5‐carbon ring, and are biosynthesized from membrane phospholipid derived arachidonic acid through the arachidonate cyclooxygenase (COX) pathway with the help of various t...
Michio Hashimoto, Shahdat Hossain
Fatty acid constitutes the foundation cell membranes, provides metabolic energy, affects functions of membrane-bound enzymes/receptors, conducts signaling cascades, and helps in learning-related memory cognition in mammals, including humans. Structurally, the fatty acids are of two kinds: saturated ...
Michio Hashimoto, Shahdat Hossain, Osamu Shido
To determine the differential effects of docosahexaenoic (DHA) and eicosapentaenoic (EPA) acid on platelet membrane fluidity under hypercholesterolemic conditions. DHA and EPA were orally administered (300 mg/kg body weight(.)day) to hypercholesterolemic rats for 12 weeks. Membrane fluidity, evaluat...
Minoru Watanabe, Toshio Kumai, Naoki Matsumoto, Masami Tanaka et al.
A relatively large amount of human liver tissue was required to determine the exact activity of human hepatic CYP3A. Although, the quantity of available human liver tissue samples is limited. We measured levels of CYP3A4 mRNA by RT-PCR with a radiolabeled primer specific for CYP3A4 and compared mRNA...
Emma Magavern, Benjamin M. Jacobs, Helen R. Warren, Gherardo Finocchiaro et al.
Cytochrome P450 family 2 subfamily C member 19 (CYP2C19) is a hepatic enzyme involved in the metabolism of clopidogrel from a prodrug to its active metabolite. Prior studies of genetic polymorphisms in CYP2C19 and their relationship with clinical efficacy have not included South Asian populations. T...
Abderrahim Ziyyat, Hassane Mekhfi, Mohamed Bnouham, Abdelhafid Tahri et al.
Arbutus unedo L. (Ericaceae) is used in oriental Morocco to treat arterial hypertension. We studied its vasodilator effect and mechanisms of action in vitro. The root aqueous extract of Arbutus (0.25 mg/mL) produced a relaxation of noradrenaline-precontracted ring preparations of rat aorta with inta...
Ejim Chijioke Franklin, Monjurul Haq, Vikash Chandra Roy, Jin‐Seok Park et al.
Every year, a large amount of by-products produced by fish processing industries is discarded or used for less profitable purposes. In this study, we will describe a technique for producing high-quality, edible oil from the viscera of yellowtail fish (Seriola quinqueradiata) which can be served as a...
Michio Hashimoto, Masanori Katakura, Shahdat Hossain, Azizur Rahman et al.
Background Docosahexaenoic acid (DHA, C22:6, n-3) ameliorates the memory-related learning deficits of Alzheimer's disease (AD), which is characterized by fibrillar amyloid deposits in the affected brains. Here, we have investigated whether DHA-induced inhibition of Amyloid β-peptide(25-35) (Aβ(25-35...
Prodip Kumar Baral, Mohammad Tohidul Amin, Md. Mamun Or Rashid, Mohammad Salim Hossain
Pooled evidence conveys the association between polyunsaturated fatty acids and infectious disease. SARS-CoV-2, an enveloped mRNA virus, was also reported to interact with polyunsaturated fatty acids. The present review explores the possible mode of action, immunology, and consequences of these poly...