Seema A. Bhat, Helen G. Coleman, Foad Yousef, B. T. Johnston et al.
BACKGROUND: Barrett's esophagus (BE) is a premalignant lesion that predisposes to esophageal adenocarcinoma. However, the reported incidence of esophageal adenocarcinoma in patients with BE varies widely. We examined the risk of malignant progression in patients with BE using data from the Northern ...
Mark G. O’Doherty, Neal D. Freedman, Albert R. Hollenbeck, Arthur Schatzkin et al.
OBJECTIVE: The incidence of oesophageal adenocarcinoma (EAC) has increased rapidly over the past 40 years and accumulating evidence suggests that obesity, as measured by body mass index (BMI), is a major risk factor. It remains unclear whether abdominal obesity is associated with EAC and gastric ade...
Paolo Bossi, Salvatore Lo Vullo, Marco Guzzo, Luigi Mariani et al.
Background Data on preoperative chemotherapy in resectable oral cavity cancer are conflicting. We present the long-term results of a randomized trial of induction chemotherapy in resectable oral cavity cancer. Patients and methods A randomized, parallel, multicentre trial evaluated the impact of thr...
YaLi Deng, Derong Tang, Pan‐Fei Hou, Weitao Shen et al.
A number of studies have identified that gut microbiota influences the development of cancer. However, there is little known about gut microbiota and esophageal cancer (EC). The aim of this study was to investigate the gut microbiota profile associated with EC. In this study, 23 patients with EC and...
Richard D. Marks, Hugh J. Scruggs, Keene M. Wallace
From 1960 through 1973, 415 patients with carcinoma of the esophagus were treated with radiation therapy. Three hundred and thirty-two patients had planned preoperative irradiation to a dose of 4500 rads in 18 fractions, and 101 of these had subsequent resections with either colon or stomach replace...
Claire Palles, Laura Chegwidden, Xinzhong Li, John M. Findlay et al.
BACKGROUND & AIMS: Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within the HLA region) and on 16q23, where the closest protein-coding gene is FOXF1. Subse...
Merrill S. Kies, Steven T. Rosen, Tat-Kin Tsang, Ramananda M. Shetty et al.
A combined treatment program consisting of chemotherapy with cisplatin and infusion 5-fluorouracil (5-FU) for three cycles followed by esophagectomy or radiation, or both, has been conducted in 26 patients with squamous cancer of the esophagus localized to the primary site. Eleven patients had objec...
Reza Pakzad, Abdollah Mohammadian-Hafshejani, Bahman Khosravi, Shahin Soltani et al.
BACKGROUND: Esophageal cancer is the most common cancer in less developed countries. It is necessary to understand epidemiology of the cancer for planning. The aim of this study was to evaluate the incidence and mortality of esophageal cancer, and its relationship with Human Development Index (HDI) ...
Debasish Das, Savid Ishaq, Rebecca Harrison, Kiran Kosuri et al.
OBJECTIVES: To assess the variation in practice of Barrett's esophagus (BE) management in comparison with accepted international guidelines before and after the introduction of a large BE randomized controlled trial (RCT) with protocols including those of tissue sampling. DESIGN: A validated anonymi...
CM Gleeson, JM Sloan, DT McManus, Perry Maxwell et al.
This study examined the association between 17p allelic loss, p53 gene mutation, p53 protein expression and DNA aneuploidy in a series of adenocarcinomas arising in the oesophagus and gastric cardia. 17p allelic loss was detected in 79% (15 of 19) of oesophageal and in 83% (29 of 35) of gastric aden...
Jonathan Shenfine, Paul McNamee, Nick Steen, J Bond et al.
OBJECTIVES: To compare whether treatment with self-expanding metal stents (SEMS) is more cost-effective than treatment with conventional modalities in patients with inoperable oesophageal cancer. Quality of life effects were also considered. DESIGN: A multicentre pragmatic, randomised controlled tri...
Hong Fan, Dongsheng Liu, Xuemei Qiu, Fengchang Qiao et al.
BACKGROUND: DNA-methyltransferase (DNMT)-3A plays an important role in the development of embryogenesis and the generation of aberrant methylation in carcinogenesis. The aim of this study was to investigate the role of a DNMT3A promoter genetic variant on its transcriptional activity and to evaluate...
Zhan Wu, Rongjun Ge, Minli Wen, Gaoshuang Liu et al.
Automatic and accurate esophageal lesion classification and segmentation is of great significance to clinically estimate the lesion statuses of the esophageal diseases and make suitable diagnostic schemes. Due to individual variations and visual similarities of lesions in shapes, colors, and texture...
Mark G. O’Doherty, Marie M. Cantwell, Liam Murray, Lesley Anderson et al.
The aim of our study was to investigate whether dietary fat and meat intakes are associated with reflux esophagitis (RE), Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). In this all-Ireland case-control study, dietary intake data were collected using a food frequency questionnaire in 2...
Tianshu Liu, Yuxian Bai, Xiaoyan Lin, Wěi Li et al.
First-line chemotherapy for advanced/metastatic human epidermal growth factor receptor 2 (HER2)-negative gastric/gastroesophageal junction cancer (GC/GEJC) has poor median overall survival (OS; <1 year). We report efficacy and safety results from Chinese patients in the phase III global CheckMate 64...