Patrick Munk, Christian Brinch, Frederik Duus Møller, Thomas Nordahl Petersen et al.
Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 7...
Joris Deelen, Marian Beekman, Hae‐Won Uh, Linda Broer et al.
The genetic contribution to the variation in human lifespan is ∼ 25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We performed a genome-wide association meta-analysis of 7729 long-lived individuals of European descent...
Terry Melton, Raymond J. Peterson, Alan J. Redd, N. Saha et al.
Polynesian genetic affinities to populations of Asia were studied using mtDNA markers. A total of 1,037 individuals from 12 populations were screened for a 9-bp deletion in the intergenic region between the COII and tRNA(Lys) genes that approaches fixation in Polynesians. Sequence-specific oligonucl...
J. Mellor, Edward C. Holmes, L M Jarvis, P.L. Yap et al.
Genotypes of hepatitis C virus (HCV) present within 104 samples from HCV-infected individuals from Africa, the Middle East, the Indian subcontinent and South-East Asia were identified by sequence comparisons in the core and NS-5 regions. Relatively short sequences (such as the 222 bp fragment of NS-...
WHO/OIE/FAO H5N1 Evolution Working Group
BACKGROUND: Continued evolution of highly pathogenic avian influenza A (H5N1) throughout many regions of the eastern hemisphere has led to the emergence of new phylogenetic groups. A total of 1637 new H5N1 hemagglutinin (HA) sequences have become available since the previous nomenclature recommendat...
Marieke S. van de Loosdrecht, Abdeljalil Bouzouggar, Louise Humphrey, Cosimo Posth et al.
North Africa is a key region for understanding human history, but the genetic history of its people is largely unknown. We present genomic data from seven 15,000-year-old modern humans, attributed to the Iberomaurusian culture, from Morocco. We find a genetic affinity with early Holocene Near Easter...
Dong‐Dong Wu, Xiangdong Ding, Sheng Wang, Jan M. Wójcik et al.
Species of the Bos genus, including taurine cattle, zebu, gayal, gaur, banteng, yak, wisent and bison, have been domesticated at least four times and have been an important source of meat, milk and power for many human cultures. We sequence the genomes of gayal, gaur, banteng, wisent and bison, and ...
Audra E. Devoto, Joanne M. Santini, Matthew R. Olm, Karthik Anantharaman et al.
Bacteriophages (phages) dramatically shape microbial community composition, redistribute nutrients via host lysis and drive evolution through horizontal gene transfer. Despite their importance, much remains to be learned about phages in the human microbiome. We investigated the gut microbiomes of hu...
V. H. Kirpalani, Norman B. Macintosh
Jan Dhaene, Andreas Tsanakas, Emiliano A. Valdez, Steven Vanduffel
A bstract This article develops a unifying framework for allocating the aggregate capital of a financial firm to its business units. The approach relies on an optimization argument, requiring that the weighted sum of measures for the deviations of the business unit's losses from their respective all...
Richard J. Abdill, Elizabeth M. Adamowicz, Ran Blekhman
The importance of sampling from globally representative populations has been well established in human genomics. In human microbiome research, however, we lack a full understanding of the global distribution of sampling in research studies. This information is crucial to better understand global pat...
Prajoy Podder, Tanvir Zaman Khan, Mamdudul Haque Khan, Mezbahur Rahman
In the emerging field of medical image processing, computer vision, pattern recognition and other digital signal processing applications, window technique is vastly used. A window function is a mathematical function that is zero-valued outside of some chosen interval. When another function is multip...
David M. Geiser, Abdullah M. S. Al‐Hatmi, Takayuki Aoki, Tsutomu Arie et al.
Scientific communication is facilitated by a data-driven, scientifically sound taxonomy that considers the end-user’s needs and established successful practice. In 2013, the Fusarium community voiced near unanimous support for a concept of Fusarium that represented a clade comprising all agricultura...
Russell Davidson, James G. MacKinnon
We provide a theoretical framework in which to study the accuracy of bootstrap P values, which may be based on a parametric or nonparametric bootstrap. In the parametric case, the accuracy of a bootstrap test will depend on the shape of what we call the critical value function. We show that, in many...
Peter Taylor
My purpose here is to provide a coherent account of inclusive fitness techniques, accessible to a mathematically literate graduate student in evolutionary biology, and to relate these to standard one-locus genetic models. I begin in Sect. 2 with a general formulation of evolutionary stability; in Se...