Hannah Blencowe, Simon Cousens, B. Modell, Joy E Lawn
BACKGROUND: Neural tube defects (NTDs) remain an important, preventable cause of mortality and morbidity. High-income countries have reported large reductions in NTDs associated with folic acid supplementation or fortification. The burden of NTDs in low-income countries and the effectiveness of foli...
Verónica Miguel, Jessica Tituaña, J. Ignacio Herrero, Laura Herrero et al.
Chronic kidney disease (CKD) remains a major epidemiological, clinical, and biomedical challenge. During CKD, renal tubular epithelial cells (TECs) present a persistent inflammatory and profibrotic response. Fatty acid oxidation (FAO), the main source of energy for TECs, is reduced in kidney fibrosis...
Sriram Krishnaswamy, W R Church, Michael E. Nesheim, Kenneth G. Mann
The kinetics of the activation of human prothrombin catalyzed by human prothrombinase was studied using the fluorescent alpha-thrombin inhibitor dansylarginine-N-(3-ethyl-1,5-pentanediyl)amide (DAPA). Prothrombinase proteolytically activates prothrombin to alpha-thrombin by cleavages at Arg273-Thr27...
Mary V. Gamble, Xinhua Liu, Habibul Ahsan, J. Richard Pilsner et al.
Chronic exposure to arsenic is occurring throughout South and East Asia due to groundwater contamination of well water. Variability in susceptibility to arsenic toxicity may be related to nutritional status. Arsenic is methylated to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) via one...
Emily R. Smith, Anuraj H. Shankar, Lee Wu, Said Aboud et al.
BACKGROUND: Micronutrient deficiencies are common among women in low-income and middle-income countries. Data from randomised trials suggest that maternal multiple micronutrient supplementation decreases the risk of low birthweight and potentially improves other infant health outcomes. However, hete...
Marjorie J Haskell, Kazi M. Jamil, Ferdaus Hassan, Janet M Peerson et al.
Background Recent evidence suggests that the vitamin A equivalency of beta-carotene from plant sources is lower than previously estimated. Objective We assessed the effect of 60 d of daily supplementation with 750 microg retinol equivalents (RE) of either cooked, puréed sweet potatoes; cooked, purée...
Mary V. Gamble, Xinhua Liu, Habibul Ahsan, J. Richard Pilsner et al.
Background Populations in South and East Asia and many other regions of the world are chronically exposed to arsenic-contaminated drinking water. To various degrees, ingested inorganic arsenic (InAs) is methylated to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) via folate-dependent on...
Habibul Ahsan, Yu Chen, Muhammad G. Kibriya, Vesna Slavkovich et al.
We conducted a case-control study to investigate interindividual variability in susceptibility to health effects of inorganic arsenic due to arsenic metabolism efficiency, genetic factors, and their interaction. A total of 594 cases of arsenic-induced skin lesions and 1,041 controls was selected fro...
Fahmida Tofail, Lars Åke Persson, Shams El Arifeen, Jena Hamadani et al.
Background Few data exist for the effects of multiple micronutrient (MM) or food supplementation to undernourished pregnant women on their offsprings' development. Objective We aimed to compare the effects on infant development of early (8-10 wk gestation) or usual ( approximately 17 wk gestation) s...
Lars Åke Persson, Shams El Arifeen, Eva‐Charlotte Ekström, Kathleen M. Rasmussen et al.
CONTEXT: Nutritional insult in fetal life and small size at birth are common in low-income countries and are associated with serious health consequences. OBJECTIVES: To test the hypothesis that prenatal multiple micronutrient supplementation (MMS) and an early invitation to food supplementation woul...
Caroline Fall, David J. Fisher, Clive Osmond, Barrie Margetts
BACKGROUND: Multiple micronutrient deficiencies are common among women in low-income countries and may adversely affect pregnancy outcomes. OBJECTIVE: This meta-analysis reports the effects on newborn size and duration of gestation of multiple micronutrient supplementation mainly compared with iron ...
J. Richard Pilsner, Xinhua Liu, Habibul Ahsan, Vesna Ilievski et al.
Background Studies in cell culture and animal models indicate that arsenic exposure induces modifications in DNA methylation, including genome-wide DNA hypomethylation. It is not known whether arsenic exposure influences genomic DNA methylation in human populations chronically exposed to arsenic-con...
Brandon L. Pierce, Muhammad G. Kibriya, Tong Lin, Farzana Jasmine et al.
Arsenic contamination of drinking water is a major public health issue in many countries, increasing risk for a wide array of diseases, including cancer. There is inter-individual variation in arsenic metabolism efficiency and susceptibility to arsenic toxicity; however, the basis of this variation ...
Shi Wu Wen, Xi-Kuan Chen, Marc Rodger, Ruth Rennicks White et al.
Objective The objective of the study was to evaluate the association between folic acid supplementation in early second trimester and the risk of developing preeclampsia. Study design We carried out a prospective cohort study between October 2002-December 2005. We recruited women who had their prena...
J. Richard Pilsner, Xinhua Liu, Habibul Ahsan, Vesna Ilievski et al.
BACKGROUND: Arsenic methylation relies on folate-dependent one-carbon metabolism and facilitates urinary As elimination. Clinical manifestations of As toxicity vary considerably among individuals and populations, and poor methylation capacity is thought to confer greater susceptibility. OBJECTIVE: A...