Monika Karmin, Lauri Saag, Mário Vicente, Melissa A. Wilson Sayres et al.
It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ...
Luca Pagani, Daniel J. Lawson, Evelyn Jagoda, Alexander Mörseburg et al.
High-coverage whole-genome sequence studies have so far focused on a limited number of geographically restricted populations, or been targeted at specific diseases, such as cancer. Nevertheless, the availability of high-resolution genomic data has led to the development of new methodologies for infe...
Terry Melton, Raymond J. Peterson, Alan J. Redd, N. Saha et al.
Polynesian genetic affinities to populations of Asia were studied using mtDNA markers. A total of 1,037 individuals from 12 populations were screened for a 9-bp deletion in the intergenic region between the COII and tRNA(Lys) genes that approaches fixation in Polynesians. Sequence-specific oligonucl...
Marieke S. van de Loosdrecht, Abdeljalil Bouzouggar, Louise Humphrey, Cosimo Posth et al.
North Africa is a key region for understanding human history, but the genetic history of its people is largely unknown. We present genomic data from seven 15,000-year-old modern humans, attributed to the Iberomaurusian culture, from Morocco. We find a genetic affinity with early Holocene Near Easter...
Cristian Capelli, James F. Wilson, Martin Richards, Michael P. H. Stumpf et al.
Modern humans reached Southeast Asia and Oceania in one of the first dispersals out of Africa. The resulting temporal overlap of modern and archaic humans-and the apparent morphological continuity between them-has led to claims of gene flow between Homo sapiens and H. erectus. Much more recently, an...
AC Pounds, Ronald Grigg, Theeravat Mongkolaussavaratana
Abstract The use of a new amino acid reagent 1,8-diazafluoren-9-one (DFO), which produces a highly fluorescent species with latent fingerprints on paper, is described. Spectral characteristics of the fluorescent fingerprint show excitation (λex approximately 470 nm) and emission (λex approximately 5...
Maximilian Larena, James McKenna, Federico Sánchez‐Quinto, Carolina Bernhardsson et al.
Multiple lines of evidence show that modern humans interbred with archaic Denisovans. Here, we report an account of shared demographic history between Australasians and Denisovans distinctively in Island Southeast Asia. Our analyses are based on ∼2.3 million genotypes from 118 ethnic groups of the P...
Marina Silva, Marisa Oliveira, Daniel Vieira, Andreia Brandão et al.
BACKGROUND: India is a patchwork of tribal and non-tribal populations that speak many different languages from various language families. Indo-European, spoken across northern and central India, and also in Pakistan and Bangladesh, has been frequently connected to the so-called "Indo-Aryan invasions...
Michelle A. Peck, Kimberly Sturk‐Andreaggi, Jacqueline Tyler Thomas, Robert S. Oliver et al.
Generating mitochondrial genome (mitogenome) data from reference samples in a rapid and efficient manner is critical to harnessing the greater power of discrimination of the entire mitochondrial DNA (mtDNA) marker. The method of long-range target enrichment, Nextera XT library preparation, and Illum...
Kai Tätte, Luca Pagani, Ajai Kumar Pathak, Sulev Kõks et al.
Surrounded by speakers of Indo-European, Dravidian and Tibeto-Burman languages, around 11 million Munda (a branch of Austroasiatic language family) speakers live in the densely populated and genetically diverse South Asia. Their genetic makeup holds components characteristic of South Asians as well ...
Erin M. Gorden, Kimberly Sturk‐Andreaggi, Charla Marshall
DNA sequence damage from cytosine deamination is well documented in degraded samples, such as those from ancient and forensic contexts. This study examined the effect of a DNA repair treatment on mitochondrial DNA (mtDNA) from aged and degraded skeletal samples. DNA extracts from 21 non-probative, d...
Fábio Silva, Alison Weisskopf, Cristina Castillo, Charlene Murphy et al.
We model the prehistoric dispersals of two rice varieties, japonica and proto- indica, across Asia using empirical evidence drawn from an archaeobotanical dataset of 400 sites from mainland East, Southeast and South Asia. The approach is based on regression modelling wherein goodness of fit is obtai...
Shagun Aggarwal, Shubha R. Phadke
Medical genetics and genomic medicine in India: current status and opportunities ahead. India is the sixth largest country of the world in size and with a population 1.21 billion (http://www.censusindia.gov.in) has the distinction of being the second most populous country of the world, housing 17.5%...
Yue Li, Kazumichi Fujiwara, Naoki Osada, Yosuke Kawai et al.
The Eurasian house mouse Mus musculus is useful for tracing prehistorical human movement related to the spread of farming. We determined whole mitochondrial DNA (mtDNA) sequences (ca. 16,000 bp) of 98 wild-derived individuals of two subspecies, M. m. musculus (MUS) and M. m. castaneus (CAS). We reve...
Kathryn J. Hunt, Charlotte A. Roberts, Casey L. Kirkpatrick
This study summarizes data from 154 paleopathological studies documenting 272 archaeologically recovered individuals exhibiting skeletal or soft tissue evidence of cancer (malignant neoplastic disease) between 1.8 million years ago and 1900 CE. The paper reviews and summarizes the temporal, spatial ...