Seema A. Bhat, Helen G. Coleman, Foad Yousef, B. T. Johnston et al.
BACKGROUND: Barrett's esophagus (BE) is a premalignant lesion that predisposes to esophageal adenocarcinoma. However, the reported incidence of esophageal adenocarcinoma in patients with BE varies widely. We examined the risk of malignant progression in patients with BE using data from the Northern ...
Paul Richardson, Christopher J. Hawkey, W. A. Stack
Proton pump inhibitors (PPIs) are drugs which irreversibly inhibit proton pump (H+/K+ ATPase) function and are the most potent gastric acid-suppressing agents in clinical use. There is now a substantial body of evidence showing improved efficacy of PPIs over the histamine H2 receptor antagonists and...
P. S. Hunt, Alastair M. Connell, Tom Smiley
This study was prompted by a clinical association noted between reflux oesophagitis and upper oesophageal disorders. Patients with reflux oesophagitis have been shown to have a significantly raised resting cricopharyngeal pressure. Patients with reflux oesophagitis (36%) complaining of dysphagia loc...
Nick Banatvala, Gareth Davies, Y. Abdi, Louisa Clements et al.
A high prevalence of metronidazole resistance in Helicobacter pylori is reported in developing countries. This study examined whether migrants referred for diagnostic gastroscopy at a United Kingdom centre (n = 54), had a higher prevalence of metronidazole resistance than subjects born in the United...
Debasish Das, Savid Ishaq, Rebecca Harrison, Kiran Kosuri et al.
OBJECTIVES: To assess the variation in practice of Barrett's esophagus (BE) management in comparison with accepted international guidelines before and after the introduction of a large BE randomized controlled trial (RCT) with protocols including those of tissue sampling. DESIGN: A validated anonymi...
Sanjida Akter, Md. Rajib Hassan, Mohammad Shahriar, Nahia Akter et al.
INTRODUCTION: Studies have shown that proton pump inhibitors (PPIs) increase the brain burden of amyloid-beta (Aβ) and also create vitamin B12 deficiency. However, these two phenomena have deleterious effect on cognition and Alzheimer's disease (AD). Since the use of PPIs has increased tremendously ...
Mark G. O’Doherty, Marie M. Cantwell, Liam Murray, Lesley Anderson et al.
The aim of our study was to investigate whether dietary fat and meat intakes are associated with reflux esophagitis (RE), Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). In this all-Ireland case-control study, dietary intake data were collected using a food frequency questionnaire in 2...
J. Athene Lane, Liam Murray, Sian Noble, Matthias Egger et al.
OBJECTIVE: To determine the impact of a community based Helicobacter pylori screening and eradication programme on the incidence of dyspepsia, resource use, and quality of life, including a cost consequences analysis. DESIGN: H pylori screening programme followed by randomised placebo controlled tri...
Peter Speelman, Golam Rabbani, Klaus Bukhave, J Rask-Madsen
Supraphysiologic doses of prostaglandins (PGs) mimic the effect of cholera toxin and cAMP in the small intestine, but not all observations are explicable in terms of the theory that links PGs to cAMP. Because no data exist on endogenous PGs in human cholera we measured PGE2 concentrations in jejunal...
Helen G. Mulholland, Marie M. Cantwell, Lesley Anderson, Brian T. Johnston et al.
Objective To examine the association between dietary glycemic index (GI), glycemic load (GL), total carbohydrate, sugars, starch, and fiber intakes and the risk of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma. Methods In an all-Ireland study, dietary information was collect...
Shanmugarajah Rajendra, S. Alahuddin
Sirs, In relation to the recent article by Lu et al. on the prevalence, social impact and health-seeking behaviour of irritable bowel syndrome patients in Taiwan,1 we would like to share our own prevalence data on irritable bowel syndrome in a multi-racial Asian population. It is widely believed tha...
Shafiqul Alam Sarker, MM Rahman, Dilip Mahalanabis, Pradip Kumar Bardhan et al.
Although H. pylori is well established as an etiological agent of type B gastritis and a predisposing factor for peptic ulcer, knowledge about its transmission is unclear. In this study we examined the prevalence of H. pylori infection in the family members of index infants infected with this organi...
Jagadish C Das, Nibedita Paul
Helicobacter pylori is one of the commonest bacterial pathogens in human. The organism is associated with development of peptic ulcer diseases, lymphoproliferative disorders and gastric cancer. Residence in a developing country, poor socio-economic conditions and genetic predisposition are regarded ...
Shafiqul Alam Sarker, Dilip Mahalanabis, Pius Hildebrand, Margubur Rahaman et al.
The aim of this study was to determine the age-specific prevalence of Helicobacter pylori infection in infants and children aged 1-99 months from a poor periurban community in Bangladesh. We also examined the frequency of infection among infants and their 53 immediate family members and evaluated th...
Qi Dai, Marie M. Cantwell, Liam Murray, Wei Zheng et al.
Evidence suggests a role of Mg and the ratio of Ca:Mg intakes in the prevention of colonic carcinogenesis. The association between these nutrients and oesophageal adenocarcinoma - a tumour with increasing incidence in developed countries and poor survival rates - has yet to be explored. The aim of t...