Cathryn M. Lewis, Douglas F. Levinson, Lesley H. Wise, Lynn E. DeLisi et al.
Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To assess evidence for linkage across studies, rank-based genome scan meta-analysis (GSMA) was applied to da...
Richard E. Straub, Yuxin Jiang, Charles J. MacLean, Yunlong Ma et al.
Prior evidence has supported the existence of multiple susceptibility genes for schizophrenia. Multipoint linkage analysis of the 270 Irish high-density pedigrees that we have studied, as well as results from several other samples, suggest that at least one such gene is located in region 6p24-21. In...
Derek Klarin, The VA Million Veteran Program, Scott M. Damrauer, Kelly Cho et al.
The Million Veteran Program (MVP) was established in 2011 as a national research initiative to determine how genetic variation influences the health of US military veterans. Here we genotyped 312,571 MVP participants using a custom biobank array and linked the genetic data to laboratory and clinical...
Georg Ehret, Teresa Ferreira, Daniel I. Chasman, Anne Jackson et al.
To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 ...
Norihiro Kato, CARDIo GRAMplusCD, LifeLines Cohort Study, Marie Loh et al.
We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10−11 to 5.0 × 10−21). ...
Sagiv Shifman, Martina Johannesson, Michal Bronstein, Sam X Chen et al.
Sex differences in schizophrenia are well known, but their genetic basis has not been identified. We performed a genome-wide association scan for schizophrenia in an Ashkenazi Jewish population using DNA pooling. We found a female-specific association with rs7341475, a SNP in the fourth intron of th...
CARDIoGRAMplusC4D, Joanna M. M. Howson, EPIC-CVD, Wei Zhao et al.
Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await identification. An efficient discovery strategy may...
Wei Zhao, Asif Rasheed, Emmi Tikkanen, Jung‐Jin Lee et al.
To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D...
Mandy Ng, Douglas F. Levinson, Stephen V. Faraone, Brian K. Suarez et al.
A genome scan meta-a nalysis (GSMA) was carried out on 32 independent genome-wide linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected with schizophrenia (SCZ) or related disorders. The primary GSMA divided the autosomes into 120 bins, rank-ordered the bins within ea...
Joris Deelen, Marian Beekman, Hae‐Won Uh, Linda Broer et al.
The genetic contribution to the variation in human lifespan is ∼ 25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We performed a genome-wide association meta-analysis of 7729 long-lived individuals of European descent...
Dieter B. Wildenauer, Sibylle G. Schwab, Margot Albus, Joachim Hallmayer et al.
In response to reported schizophrenia linkage findings on chromosomes 3, 6 and 8, fourteen research groups genotyped 14 microsatellite markers in an unbiased, collaborative (New) sample of 403-567 informative pedigrees per marker, and in the Original sample which produced each finding (the Johns Hop...
Richard E. Straub, Charles J. MacLean, Rory Martin, Yunlong Ma et al.
In our genomic scan of 265 Irish families with schizophrenia, we have thus far generated modest evidence for the presence of vulnerability genes in three chromosomal regions, i.e., 5q21-q31, 6p24-p22, and 8p22-p21. Outside of those regions, of all markers tested to date, D10S674 produced one of the ...
Derek Klarin, Shefali S. Verma, Renae Judy, Ozan Dikilitas et al.
Background: Abdominal aortic aneurysm (AAA) is an important cause of cardiovascular mortality; however, its genetic determinants remain incompletely defined. In total, 10 previously identified risk loci explain a small fraction of AAA heritability. Methods: We performed a genome-wide association stu...
Sarah Finer, Hilary C. Martin, Ahsan Khan, Karen A. Hunt et al.
Cohort profile in a nutshell: - East London Genes & Health (ELGH) is a large scale, community genomics and health study (to date >30,000 volunteers; target 100,000 volunteers). - ELGH was set up in 2015 to gain deeper understanding of health and disease, and underlying genetic influences, in people ...
A. Mesut Erzurumluoglu, Mengzhen Liu, Victoria E. Jackson, Daniel R. Barnes et al.
Abstract Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tested up to 235,116 single nucleotide varia...