Mohammad Anwar Hossain, Piyatida Pukclai, Jaime A. Teixeira da Silva, Masayuki Fujita
Heavy metal (HM) toxicity is one of the major abiotic stresses leading to hazardous effects in plants. A common consequence of HM toxicity is the excessive accumulation of reactive oxygen species (ROS) and methylglyoxal (MG), both of which can cause peroxidation of lipids, oxidation of protein, inac...
Mirza Hasanuzzaman, Kamrun Nahar, Taufika Islam Anee, Masayuki Fujita
Glutathione (GSH; γ-glutamyl-cysteinyl-glycine) is a small intracellular thiol molecule which is considered as a strong non-enzymatic antioxidant. Glutathione regulates multiple metabolic functions; for example, it protects membranes by maintaining the reduced state of both α-tocopherol and zeaxanth...
Sarvajeet Singh Gill, Naser A. Anjum, Mirza Hasanuzzaman, Ritu Gill et al.
Abiotic stresses such as salinity, drought, clilling, heavy metal are the major limiting factors for crop productivity. These stresses induce the overproduction of reactive oxygen species (ROS) which are highly reactive and toxic, which must be minimized to protect the cell from oxidative damage. Th...
Md. Abdul Hannan, Raju Dash, Abdullah Al Mamun Sohag, Md. Nazmul Haque et al.
Oxidative stress (OS) plays a critical role in the pathophysiology of several brain-related disorders, including neurodegenerative diseases and ischemic stroke, which are the major causes of dementia. The Nrf2-ARE (nuclear factor erythroid 2-related factor 2/antioxidant responsive element antioxidan...
Partha Biswas, Dipta Dey, Polash Kumar Biswas, Tanjim Ishraq Rahaman et al.
Reactive oxygen species (ROS) induce carcinogenesis by causing genetic mutations, activating oncogenes, and increasing oxidative stress, all of which affect cell proliferation, survival, and apoptosis. When compared to normal cells, cancer cells have higher levels of ROS, and they are responsible fo...
Naser A. Anjum, Ritu Gill, Manjeri Kaushik, Mirza Hasanuzzaman et al.
Sulfur (S) stands fourth in the list of major plant nutrients after N, P, and K. Sulfate (SO4 (2-)), a form of soil-S taken up by plant roots is metabolically inert. As the first committed step of S-assimilation, ATP-sulfurylase (ATP-S) catalyzes SO4 (2-)-activation and yields activated high-energy ...
Md. Sahab Uddin, Abdullah Al Mamun, Md. Jakaria, S. Thangapandiyan et al.
Neurological disorders represent a great challenge and are the leading cause of death and disability globally. Although numerous complicated mechanisms are involved in the progressions of chronic and acute neurodegenerative disorders, most of the diseases share mutual pathogenic features such as oxi...
Muzahidul I. Anik, Niaz Mahmud, Abdullah Al Masud, Md Ishak Khan et al.
Research on the role of reactive oxygen species (ROS) in the aging process has advanced significantly over the last two decades. In light of recent findings, ROS takes part in the aging process of cells along with contributing to various physiological signaling pathways. Antioxidants being cells' na...
Md. Ataur Rahman, Md. Abdul Hannan, Raju Dash, MD. Hasanur Rahman et al.
Bioactive plant derived compounds are important for a wide range of therapeutic applications, and some display promising anticancer properties. Further evidence suggests that phytochemicals modulate autophagy and apoptosis, the two crucial cellular pathways involved in the underlying pathobiology of...
Md. Rezaul Islam, Abdur Rauf, Shopnil Akash, Sadiya Islam Trisha et al.
The curry powder spices turmeric (Curcuma longa L.), which contains curcumin (diferuloylmethane), an orange-yellow chemical. Polyphenols are the most commonly used sources of curcumin. It combats oxidative stress and inflammation in diseases, such as hyperlipidemia, metabolic syndrome, arthritis, an...
Shiful Islam, Iffat Rahman, Tahmina Islam, Ajit Ghosh
Glutathione S-transferase (GST) refers to one of the major detoxifying enzymes that plays an important role in different abiotic and biotic stress modulation pathways of plant. The present study aimed to a comprehensive genome-wide functional characterization of GST genes and proteins in tomato (Sol...
Shiful Islam, Saikat Das Sajib, Zakya Sultana Jui, Shatil Arabia et al.
Glutathione S-transferases (GSTs) compose a family of multifunctional enzymes involved in the numerous aspects of regulating plant growth, development, and stress response. An in silico genome-wide analysis of pepper (Capsicum annuum L.) was performed to identify eighty-five GST genes that were anno...
Jun’ichi Mano, Md. Sanaullah Biswas, Koichi Sugimoto
As reactive oxygen species (ROS) play critical roles in plants to determine cell fate in various physiological situations, there is keen interest in the biochemical processes of ROS signal transmission. Reactive carbonyl species (RCS), the ,-unsaturated aldehydes and ketones produced from lipid pero...
Chihiro Ito, Masataka Itoigawa, Atsuko Sato, Choudhury Mahmood Hasan et al.
As part of the phytochemical studies of the plant genus Glycosmis, the constituents of the plant Glycosmis arborea were investigated. Three new carbazole alkaloids named glybomines A (1), B (2), and C (3), along with known monomeric alkaloids belonging to the carbazole, quinazoline, furoquinoline, q...
Md. Atiqur Rahman Khokon, M. Sarwar Jahan, Taniya Rahman, Mohammad Anowar Hossain et al.
Isothiocyanates (ITCs) are degradation products of glucosinolates in crucifer plants and have repellent effect on insects, pathogens and herbivores. In this study, we report that exogenously applied allyl isothiocyanate (AITC) induced stomatal closure in Arabidopsis via production of reactive oxygen...
Xinda Zou, Amrit BK, Tareq Abu‐Izneid, Ahsan Aziz et al.
Tobacco is grown in large quantities worldwide as a widely distributed commercial crop. From the harvest of the field to the process into the final product, a series of procedures generate enormous amount of waste materials that are rarely recycled. In recent years, numerous potential bioactive comp...
Shi Hyoung Kim, Jae Gwang Park, Jongsung Lee, Woo Seok Yang et al.
Even though a lot of reports have suggested the anti-inflammatory activity of kaempferol (KF) in macrophages, little is known about its exact anti-inflammatory mode of action and its immunopharmacological target molecules. In this study, we explored anti-inflammatory activity of KF in LPS-treated ma...
Abdul Khaleque, Ajit Bharti, Jianlin Gong, Phillip J. Gray et al.
Heat shock factor 1 (HSF1), the transcriptional activator of the heat shock genes, is increasingly implicated in cancer. We have shown that HSF1 binds to the corepressor metastasis-associated protein 1 (MTA1) in vitro and in human breast carcinoma samples. HSF1-MTA1 complex formation was strongly in...
Mohammed Abul Monjur Khan, Christian Ulrichs, Inga Mewis
Abstract Drought stress alters the chemical composition of plants, which can influence their tolerance to insect herbivory. To evaluate plant chemical responses to drought stress, broccoli, Brassica oleracea L. var. italica Plenck (Brassicaceae), was grown under well‐watered, drought, and water‐logg...
Divya Jain, Priya Chaudhary, Nidhi Varshney, Khandaker Sabit Bin Razzak et al.
Smoking a cigarette generates over 4000 chemicals that have a deleterious impact on each part of the human body. It produces three main severe effects on the liver organ: oncogenic, immunological, and indirect or direct toxic effects. It results in the production of cytotoxic substances, which raise...