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31+ results
Field: Genomics, phytochemicals, and oxidative stress

Current advances of functional phytochemicals in Nicotiana plant and related potential value of tobacco processing waste: A review

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Xinda Zou, Amrit BK, Tareq Abu‐Izneid, Ahsan Aziz et al.

Journal: Biomedicine & Pharmacotherapy
Year: 2021
Citations: 106

Tobacco is grown in large quantities worldwide as a widely distributed commercial crop. From the harvest of the field to the process into the final product, a series of procedures generate enormous amount of waste materials that are rarely recycled. In recent years, numerous potential bioactive comp...

Health SciencesMedicineBiochemistryOpen Access
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The Dietary Flavonoid Kaempferol Mediates Anti‐Inflammatory Responses via the Src, Syk, IRAK1, and IRAK4 Molecular Targets

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Shi Hyoung Kim, Jae Gwang Park, Jongsung Lee, Woo Seok Yang et al.

Journal: Mediators of InflammationYear: 2015Citations: 103

Even though a lot of reports have suggested the anti-inflammatory activity of kaempferol (KF) in macrophages, little is known about its exact anti-inflammatory mode of action and its immunopharmacological target molecules. In this study, we explored anti-inflammatory activity of KF in LPS-treated ma...

Health SciencesMedicineSurgeryOpen Access
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Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1

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Abdul Khaleque, Ajit Bharti, Jianlin Gong, Phillip J. Gray et al.

Journal: OncogeneYear: 2007Citations: 102

Heat shock factor 1 (HSF1), the transcriptional activator of the heat shock genes, is increasingly implicated in cancer. We have shown that HSF1 binds to the corepressor metastasis-associated protein 1 (MTA1) in vitro and in human breast carcinoma samples. HSF1-MTA1 complex formation was strongly in...

Life SciencesBiochemistry, Genetics and Molecular BiologyMolecular BiologyOpen Access
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Influence of water stress on the glucosinolate profile of <i>Brassica oleracea</i> var. <i>italica</i> and the performance of <i>Brevicoryne brassicae</i> and <i>Myzus persicae</i>

Verified

Mohammed Abul Monjur Khan, Christian Ulrichs, Inga Mewis

Journal: Entomologia Experimentalis et ApplicataYear: 2010Citations: 97

Abstract Drought stress alters the chemical composition of plants, which can influence their tolerance to insect herbivory. To evaluate plant chemical responses to drought stress, broccoli, Brassica oleracea L. var. italica Plenck (Brassicaceae), was grown under well‐watered, drought, and water‐logg...

Life SciencesBiochemistry, Genetics and Molecular BiologyMolecular Biology
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Tobacco Smoking and Liver Cancer Risk: Potential Avenues for Carcinogenesis

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Divya Jain, Priya Chaudhary, Nidhi Varshney, Khandaker Sabit Bin Razzak et al.

Journal: Journal of OncologyYear: 2021Citations: 90

Smoking a cigarette generates over 4000 chemicals that have a deleterious impact on each part of the human body. It produces three main severe effects on the liver organ: oncogenic, immunological, and indirect or direct toxic effects. It results in the production of cytotoxic substances, which raise...

Health SciencesMedicineEpidemiologyOpen Access
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Genome-Wide Identification, Characterization, and Expression Profiling of Glutathione S-Transferase (GST) Family in Pumpkin Reveals Likely Role in Cold-Stress Tolerance

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Md. Abdul Kayum, Ujjal Kumar Nath, Jong‐In Park, Manosh Kumar Biswas et al.

Journal: GenesYear: 2018Citations: 88

Plant growth and development can be adversely affected by cold stress, limiting productivity. The glutathione S-transferase (GST) family comprises important detoxifying enzymes, which play major roles in biotic and abiotic stress responses by reducing the oxidative damage caused by reactive oxygen s...

Life SciencesBiochemistry, Genetics and Molecular BiologyMolecular BiologyOpen Access
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Mapping of a novel clubroot resistance QTL using ddRAD-seq in Chinese cabbage (Brassica rapa L.)

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Rawnak Laila, Jong‐In Park, Arif Hasan Khan Robin, Sathishkumar Natarajan et al.

Journal: BMC Plant BiologyYear: 2019Citations: 87

Plasmodiophora brassicae is a soil-borne plant pathogen that causes clubroot disease, which results in crop yield loss in cultivated Brassica species. Here, we investigated whether a quantitative trait locus (QTL) in B. rapa might confer resistance to a Korean P. brassicae pathotype isolate, Seosan....

Life SciencesAgricultural and Biological SciencesPlant ScienceOpen Access
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Involvement of MAPK/NF-κB signal transduction pathways: Camellia japonica mitigates inflammation and gastric ulcer

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Md Rashedunnabi Akanda, Byung‐Yong Park

Journal: Biomedicine & PharmacotherapyYear: 2017Citations: 85

Gastric ulcer is an important risk factor for human health globally. Camellia japonica (CJ) is a plant of which the fruits are used as traditional phytomedicine for inflammatory and immunomodulatory diseases; however, the underlying molecular mechanism has not been clarified. The present study aimed...

Life SciencesBiochemistry, Genetics and Molecular BiologyMolecular Biology
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Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM

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Nuala McCabe, Conor Hanna, Steven M. Walker, David Gonda et al.

Journal: Cancer ResearchYear: 2015Citations: 78

Ataxia telangiectasia mutated (ATM) is an important signaling molecule in the DNA damage response (DDR). ATM loss of function can produce a synthetic lethal phenotype in combination with tumor-associated mutations in FA/BRCA pathway components. In this study, we took an siRNA screening strategy to i...

Life SciencesBiochemistry, Genetics and Molecular BiologyMolecular BiologyOpen Access
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Melatonin alleviates low-sulfur stress by promoting sulfur homeostasis in tomato plants

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Md. Kamrul Hasan, Chenxu Liu, Yan‐Ting Pan, Golam Jalal Ahammed et al.

Journal: Scientific ReportsYear: 2018Citations: 76

Despite involvement of melatonin (MT) in plant growth and stress tolerance, its role in sulfur (S) acquisition and assimilation remains unclear. Here we report that low-S conditions cause serious growth inhibition by reducing chlorophyll content, photosynthesis and biomass accumulation. S deficiency...

Life SciencesBiochemistry, Genetics and Molecular BiologyMolecular BiologyOpen Access
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Crosstalk between unfolded protein response and Nrf2-mediated antioxidant defense in Di-(2-ethylhexyl) phthalate-induced renal injury in quail (Coturnix japonica)

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Yi Zhao, Zheng‐Hai Du, Milton Talukder, Jia Lin et al.

Journal: Environmental PollutionYear: 2018Citations: 75

The widely used Di-(2-ethylhexyl) phthalate (DEHP) has been reported to exhibit ubiquitous environmental and global health hazards. The bioaccumulation and environmental persistence of DEHP can cause serious health hazards in wildlife animals and human. However, DEHP-induced nephrotoxicity in bird i...

Health SciencesNursingNutrition and Dietetics
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Cerevisterol Alleviates Inflammation via Suppression of MAPK/NF-κB/AP-1 and Activation of the Nrf2/HO-1 Signaling Cascade

Verified

Md Badrul Alam, Nargis Sultana Chowdhury, Md. Hossain Sohrab, Md. Sohel Rana et al.

Journal: BiomoleculesYear: 2020Citations: 73

As part of our continuous effort to find potential anti-inflammatory agents from endophytic fungi, a Fusarium solani strain, isolated from the plant Aponogeton undulatus Roxb., was investigated. Cerevisterol (CRVS) was identified from endophytic fungi, a Fusarium solani strain, and moreover exhibite...

Health SciencesMedicinePharmacologyOpen Access
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Antiproliferative and antioxidant potentials of bioactive edible vegetable fraction of <i>Achyranthes ferruginea</i> Roxb. in cancer cell line

Verified

A.S.M. Ali Reza, Md. Anwarul Haque, Joy Sarker, Shamima Nasrin et al.

Journal: Food Science & NutritionYear: 2021Citations: 67

Abstract In the present study, the aerial parts of Achyranthes ferruginea underwent investigation of their in vitro antioxidant and free radical‐scavenging activities in cell‐free conditions, their phytoconstituents using gas chromatography‐mass spectrometry (GC‐MS), and their cytotoxic activity in ...

Health SciencesMedicineBiochemistryOpen Access
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Overexpression of GmNAC085 enhances drought tolerance in Arabidopsis by regulating glutathione biosynthesis, redox balance and glutathione-dependent detoxification of reactive oxygen species and methylglyoxal

Verified

Kien Huu Nguyen, Mohammad Golam Mostofa, Yasuko Watanabe, Cuong Duy Tran et al.

Journal: Environmental and Experimental BotanyYear: 2018Citations: 67

Glutathione (GSH)-dependent detoxification mechanisms are crucial for protecting plants from the adverse effects of abiotic stresses, including drought. Plant tolerance to drought is regulated by a set of transcription factors that are considered as an integral part of signaling networks in plants. ...

Life SciencesAgricultural and Biological SciencesPlant Science
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Comprehensive genome-wide analysis of Glutathione S-transferase gene family in potato ( Solanum tuberosum L.) and their expression profiling in various anatomical tissues and perturbation conditions

Verified

Shiful Islam, Mouraj Choudhury, Al Nahian Khan Majlish, Tahmina Islam et al.

Journal: GeneYear: 2017Citations: 66

Glutathione S-transferases (GSTs) are ubiquitous enzymes which play versatile functions including cellular detoxification and stress tolerance. In this study, a comprehensive genome-wide identification of GST gene family was carried out in potato (Solanum tuberosum L.). The result demonstrated the p...

Life SciencesBiochemistry, Genetics and Molecular BiologyMolecular Biology
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