Sofie Vermeiren, Roberta Vella-Azzopardi, David Beckwée, Ann-Katrin Habbig et al.
Introduction Frailty is one of the most important concerns regarding our aging population. Evidence grows that the syndrome is linked to several important health outcomes. A general overview of frailty concepts and a comprehensive meta-analysis of their relation with negative health outcomes still l...
Shahedur Rahman, Rezuanul Islam
Sirt1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase that removes acetyl groups from various proteins. Sirt1 performs a wide variety of functions in biological systems. The current review focuses on the biological functions of Sirt1 in obesity-ass...
Aneesa Ansari, Md. Shahedur Rahman, Subbroto Kumar Saha, Forhad Karim Saikot et al.
In mammals, seven members of the sirtuin protein family known as class III histone deacetylase have been identified for their characteristic features. These distinguished characteristics include the tissues where they are distributed or located, enzymatic activities, molecular functions, and involve...
Md. Habibur Rahman, Rokeya Akter, Tanima Bhattacharya, Mohamed M. Abdel‐Daim et al.
Alzheimer’s disease (AD) is a progressive cortex and hippocampal neurodegenerative disease which ultimately causes cognitively impaired decline in patients. The AD pathogen is a very complex process, including aggregation of Aβ (β-amyloid peptides), phosphorylation of tau-proteins, and chronic infla...
Jennifer Tjia, Sarah J. Velten, Carole Parsons, Sruthi Valluri et al.
Background Overuse of unnecessary medications in frail older adults with limited life expectancy remains an understudied challenge. Objective To identify intervention studies that reduced use of unnecessary medications in frail older adults. A secondary goal was to identify and review studies focusi...
Md. Sahab Uddin, Abdullah Al Mamun, Md. Tanvir Kabir, Jamil Ahmad et al.
Neurodegenerative diseases (NDs) are characterized by disorders with progressive deterioration of the structure and/or function of neurons. Genetic mutations can lead to many NDs. Nevertheless, neurodegeneration can also take place due to several biological processes. The pathogenesis of several NDs...
John Muscedere, Melissa K. Andrew, Sean M. Bagshaw, Carole A. Estabrooks et al.
RÉSUMÉ Avec le vieillissement de la population canadienne, la fragilité – avec son risque accru du déclin fonctionnel, la détérioration de la santé, et le décès – devient de plus en plus répandue. La physiologie de la fragilité reflète son origine parmi organes et systèmes multiples. Environ un quar...
Raushanara Akter, Afrina Afrose, Md. Rashidur Rahman, Rakhi Chowdhury et al.
Natural products have long been used as drugs to treat a wide array of human diseases. The lead compounds discovered from natural sources are used as novel templates for developing more potent and safer drugs. Natural products produce biological activity by binding with biological macromolecules, si...
Alejandro Álvarez‐Bustos, Jose Antonio Carnicero‐Carreño, Juan Luis Sánchez‐Sánchez, Francisco Javier Garcia‐Garcia et al.
BACKGROUND: The association between frailty and adverse outcomes has been clearly defined. Frailty is associated with age, but different frailty evolution patterns might determine the incidence of adverse outcomes at older ages. So far, few observational studies have examined how distinct frailty tr...
Mohammad Shafiqur Rahman, Gareth Ambler, Babak Choodari‐Oskooei, Rumana Omar
BACKGROUND: When developing a prediction model for survival data it is essential to validate its performance in external validation settings using appropriate performance measures. Although a number of such measures have been proposed, there is only limited guidance regarding their use in the contex...
Fahadul Islam, Mohamed H. Nafady, Md. Rezaul Islam, Susmita Saha et al.
Alzheimer's disease (AD) is the most common cause of dementia and cognitive impairment; yet, there is currently no treatment. A buildup of Aβ, tau protein phosphorylation, oxidative stress, and inflammation in AD is pathogenic. The accumulation of amyloid-beta (Aβ) peptides in these neurocognitive a...
Alejandro Álvarez‐Bustos, Jose Antonio Carnicero‐Carreño, Betty Davies, Francisco Javier Garcia‐Garcia et al.
BACKGROUND: Frailty and sarcopenia are age-associated syndromes that have been associated with the risk of several adverse events, mainly functional decline and death, that usually coexist. However, the potential role of one of them (sarcopenia) in modulating some of those adverse events associated ...
Rubayat Khan, Saif Nirzhor, Raushanara Akter
Sirtuin 6 (SIRT6) is a nicotinamide adenine dinucleotide⁺ (NAD⁺) dependent enzyme and stress response protein that has sparked the curiosity of many researchers in different branches of the biomedical sciences. A unique member of the known Sirtuin family, SIRT6 has several different functions in mul...
Anne Hendry, Ana María Carriazo, Eliane Vanhecke, Ángel Rodríguez‐Laso
Frailty is increasingly recognised as a public health priority due to the associated demand for acute and longer term health and social care support, and the impact on the lives of individuals, caregivers and families. Integrated care is widely considered to be most effective when applied to an olde...
Guo Zhao, Junfeng Zhen, Xinyuan Liu, J.J. Guo et al.
Lysine succinylation (Ksuc) is a novel protein post-translational modification (PTM) wherein a succinyl group modifies a lysine residue. Ksuc leads to significant chemical and structural changes to the modified protein. Recent studies have shown that Ksuc might play an important role in organism phy...