Philippe Jeandet, Eduardo Sobarzo‐Sánchez, Md. Sahab Uddin, Roque Bru‐Martínez et al.
Most drugs or the natural substances reputed to display some biological activity are hydrophobic molecules that demonstrate low bioavailability regardless of their mode of absorption. Resveratrol and its derivatives belong to the chemical group of stilbenes; while stilbenes are known to possess very...
Xiao Qiang Xie, Pei Zhang, Bo Tian, Xiaoqian Chen
Sirtuin 2 (SIRT2) is a member of NAD + -dependent protein deacetylases involved in a wide range of pathophysiological processes including myocardial injury, Parkinson's disease, and Huntington's disease. However, the direct implication of SIRT2 in ischemic stroke is still unclear. In the present stu...
Sayeeda Rahman, Keerti Singh, Sameer Dhingra, Jaykaran Charan et al.
COVID-19 pandemic is inducing acute respiratory distress syndrome, multi-organ failure, and eventual death. Respiratory failure is the leading cause of mortality in the elderly population with pre-existing medical conditions. This group is particularly vulnerable to infections due to a declined immu...
Md Jamal Uddin, Mithila Farjana, Akhi Moni, Khandkar Shaharina Hossain et al.
Aging is an unavoidable part of life. The more aged we become, the more susceptible we become to various complications and damages to the vital organs, including the kidneys. The existing drugs for kidney diseases are mostly of synthetic origins; thus, natural compounds with minimal side-effects hav...
Luke Mondor, Colleen J. Maxwell, David B. Hogan, Susan E. Bronskill et al.
OBJECTIVE: In this study, we investigated the incremental 1-year direct costs of health care associated with frailty among home care recipients in Ontario with and without dementia. METHODS: We conducted a cohort study of 159,570 home care clients aged 50 years and older in Ontario, Canada in 2014/2...
Hitesh Chopra, Shabana Bibi, Fahadul Islam, Syed Umair Ahmad et al.
Resveratrol (RES) is a stilbene group of natural polyphenolic compounds in trees, peanuts, and grapes. RES is revealed with anticancer, antioxidant, anti‐inflammatory, and cardioprotective effects. Though it is proven with prominent therapeutic activity, low aqueous solubility, poor bioavailability,...
Shraddha Pradhananga, Krishna Regmi, Nasrin Razzaq, Alireza Ettefaghian et al.
OBJECTIVE: There have been few studies in which the prevalence of frailty of different ethnic groups has been assessed in multiethnic countries. The aim of this study was to evaluate the prevalence of frailty in different ethnic groups in the United Kingdom. METHODS: Anonymized electronic health rec...
Tanzir Rafe, Parvez Ahmed Shawon, Liyad Salem, Nafij Imtiyaj Chowdhury et al.
BACKGROUND: Immunity is the ultimate barrier between foreign stimuli and a host cell. Unwanted immune responses can threaten the host cells and may eventually damage a vital organ. Overproduction of inflammatory cytokines may also lead to autoimmune diseases. Inflammatory cells and pro-inflammatory ...
Patrick Redmond, Hailey Carroll, Tamasine Grimes, Rose Galvin et al.
OBJECTIVE: The aim of this study was to survey GPs and community pharmacists (CPs) in Ireland regarding current practices of medication management, specifically medication reconciliation, communication between health care providers and medication errors as patients transition in care. METHODS: A nat...
Michael Scott, Claire Scullin, Anita Hogg, Glenda Fleming et al.
<h3>Objective</h3> The objective of this review was to assess the improvement in medicines processes in Northern Ireland focusing mainly on secondary care and at the interface with primary care and also to consider the benefits of enabling technologies for the system. <h3>Methods</h3> The review was...
Abdullah Al Mamun, Mohammad Abu Sufian, Md. Sahab Uddin, Dewan Md. Sumsuzzman et al.
During the last few decades, cancer has remained one of the deadliest diseases that endanger human health, emphasizing urgent drug discovery. Cellular senescence has gained a great deal of attention in recent years because of its link to the development of cancer therapy. Senescent cells are incapab...
Faizul Islam Chowdhury, Tahmina Yasmin, Raushanara Akter, Md. Nurul Islam et al.
Objective: Resveratrol is a polyphenolic compound that possesses strong antioxidant and anti-inflammatory activities. This study evaluated the effects of resveratrol on oxidative stress, fibrosis and multiple genes regulation in the kidneys of high fat (HF) diet-fed rats. Methods: Wistar rats were f...
Mohammad Meshbahur Rahman, Mohammad Hamiduzzaman, Mst. Saleha Akter, Zaki Farhana et al.
BACKGROUND: Frailty is associated with healthy ageing, and it has been identified as a means of measuring older adults' physio-psychosocial health. We know about the ageing trends and common diseases of older adults living in South Asia, but literature to date does not widely feature their health st...
Farzana Sultana, Md. Ajijur Rahman, Tripti Rani Paul, Md Shahid Sarwar et al.
Irrational prescribing of drugs is a major health concern in developing countries like Bangladesh. A study was therefore undertaken in a hospital, situated in Rajshahi region of Bangladesh, to find the prescribing pattern and to detect the prescription errors to the admitted patients. Prescriptions ...