Yuan Zhang, Rongrong Huang, Mengjing Cheng, Lirui Wang et al.
BACKGROUND: Inflammasomes have been found to interact with the gut microbiota, and this effect is associated with depression, but the mechanisms underlying this interaction have not been elucidated in detail. RESULTS: The locomotor activity of NLRP3 KO mice was significantly greater than that of the...
Rine Christopher Reuben, Pravas Chandra Roy, Shovon Lal Sarkar, A. S. M. Rubayet Ul Alam et al.
Raw milk contains wide microbial diversity, composed mainly of lactic acid bacteria (LAB), which are used as probiotics in both human and animal husbandry. We isolated, characterized, and evaluated LAB from indigenous Bangladeshi raw milk to assess probiotic potential, including antagonistic activit...
Audra E. Devoto, Joanne M. Santini, Matthew R. Olm, Karthik Anantharaman et al.
Bacteriophages (phages) dramatically shape microbial community composition, redistribute nutrients via host lysis and drive evolution through horizontal gene transfer. Despite their importance, much remains to be learned about phages in the human microbiome. We investigated the gut microbiomes of hu...
Md. Mominur Rahman, Fahadul Islam, Md. Harun- Or-Rashid, Abdullah Al Mamun et al.
In the last two decades, considerable interest has been shown in understanding the development of the gut microbiota and its internal and external effects on the intestine, as well as the risk factors for cardiovascular diseases (CVDs) such as metabolic syndrome. The intestinal microbiota plays a pi...
Arjun S. Raman, Jeanette L. Gehrig, Siddarth Venkatesh, Hao-Wei Chang et al.
Characterizing the organization of the human gut microbiota is a formidable challenge given the number of possible interactions between its components. Using a statistical approach initially applied to financial markets, we measured temporally conserved covariance among bacterial taxa in the microbi...
Shirajum Monira, Shota Nakamura, Kazuyoshi Gotoh, Kaori Izutsu et al.
Poor health and malnutrition in preschool children are longstanding problems in Bangladesh. Gut microbiota plays a tremendous role in nutrient absorption and determining the state of health. In this study, metagenomic tool was employed to assess the gut microbiota composition of healthy and malnouri...
Richard J. Abdill, Elizabeth M. Adamowicz, Ran Blekhman
The importance of sampling from globally representative populations has been well established in human genomics. In human microbiome research, however, we lack a full understanding of the global distribution of sampling in research studies. This information is crucial to better understand global pat...
Lawrence A. David, Ana A. Weil, Edward T. Ryan, Stephen B. Calderwood et al.
UNLABELLED: Disability after childhood diarrhea is an important burden on global productivity. Recent studies suggest that gut bacterial communities influence how humans recover from infectious diarrhea, but we still lack extensive data and mechanistic hypotheses for how these bacterial communities ...
Neelendu Dey, Vitas E. Wagner, Laura V. Blanton, Jiye Cheng et al.
To understand how different diets, the consumers’ gut microbiota and the enteric nervous system (ENS) interact to regulate gut motility, we developed a gnotobiotic mouse model that mimics short-term dietary changes that happen when humans are traveling to places with different culinary traditions. S...
M. Nazmul Hoque, Arif Istiaq, Rebecca Clement, Munawar Sultana et al.
Milk microbiomes significantly influence the pathophysiology of bovine mastitis. To assess the association between microbiome diversity and bovine mastitis, we compared the microbiome of clinical mastitis (CM, n = 14) and healthy (H, n = 7) milk samples through deep whole metagenome sequencing (WMS)...
Masuma Afrin Taniya, Hea‐Jong Chung, Abdullah Al Mamun, Safaet Alam et al.
Autism spectrum disorder (ASD) is a neurological disorder that affects normal brain development. The recent finding of the microbiota-gut-brain axis indicates the bidirectional connection between our gut and brain, demonstrating that gut microbiota can influence many neurological disorders such as a...
Jiajia Jin, Liaomei Gao, Xiuli Zou, Yun Zhang et al.
Background: Preeclampsia is one of the leading causes of maternal and perinatal morbidity and is characterized by hypertension, inflammation, and placental dysfunction. Gut microbiota plays key roles in inflammation and hypertension. However, its roles and mechanisms in preeclampsia have not been fu...
Robert Y. Chen, Vanderlene L. Kung, Subhasish Das, Md. Shabab Hossain et al.
BACKGROUND: Environmental enteric dysfunction (EED) is an enigmatic disorder of the small intestine that is postulated to play a role in childhood undernutrition, a pressing global health problem. Defining the incidence of this disorder, its pathophysiological features, and its contribution to impai...
Elena de Marco Castro, Philip C. Calder, Helen M. Roche
The innate immune system responds in a rapid and non-specific manner against immunologic threats; inflammation is part of this response. This is followed by a slower but targeted and specific response termed the adaptive or acquired immune response. There is emerging evidence that dietary components...
Bhutada Sarita, Dahikar Samadhan, Md Zakir Hassan, Elena G. Kovaleva
The beneficial properties of probiotics have always been a point of interest. Probiotics play a major role in maintaining the health of Gastrointestinal Tract (GIT), a healthy digestive system is responsible for modulating all other functions of the body. The effectiveness of probiotics can be enhan...