Derek Klarin, The VA Million Veteran Program, Scott M. Damrauer, Kelly Cho et al.
The Million Veteran Program (MVP) was established in 2011 as a national research initiative to determine how genetic variation influences the health of US military veterans. Here we genotyped 312,571 MVP participants using a custom biobank array and linked the genetic data to laboratory and clinical...
Charge Diabetes Working Group, Dajiang J. Liu, VA Million Veteran Program, Gina M. Peloso et al.
We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-density-lipoprotein ch...
Paolo Zanoni, Sumeet A. Khetarpal, Daniel B. Larach, William Hancock‐Cerutti et al.
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL) cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower risk of coronary heart disease (CHD). Mice that have depleted Scarb1 (SR-BI knockout mice) have markedly elevated HDL-C l...
Bishwajit Bhowmik, Tasnima Siddiquee, Anindita Mujumder, Faria Afsana et al.
Dyslipidemia is commonly associated with diabetes (T2DM). This has been demonstrated for the Caucasian population, but few data are available for Asian Indians. The paper aims to investigate serum lipids (separately or in combination) and their association with glucose intolerance status (T2DM and p...
Md. Sharifull Islam, Ping Wei, Md Suzauddula, Ishatur Nime et al.
Metabolic syndrome (MetS) is an indicator and diverse endocrine syndrome that combines different metabolic defects with clinical, physiological, biochemical, and metabolic factors. Obesity, visceral adiposity and abdominal obesity, dyslipidemia, insulin resistance (IR), elevated blood pressure, endo...
Tejaswini Ashok, Harivarsha Puttam, Victoria Clarice A Tarnate, Sharan Jhaveri et al.
Metabolic syndrome (MS) is a collection of pathological metabolic conditions that includes insulin resistance, central or abdominal obesity, dyslipidemia, and hypertension. It affects large populations worldwide, and its prevalence is rising exponentially. There is no specific mechanism that leads t...
Annette Peters, Klaus Stark, Muntaser D. Musameh, Christopher P. Nelson et al.
Adverse levels of lipoproteins are highly heritable and constitute risk factors for cardiovascular outcomes. Hitherto, genome-wide association studies revealed 95 lipid-associated loci. However, due to the small effect sizes of these associations large sample numbers (>100 000 samples) were needed. ...
Lulu Han, Yutong Miao, Yang Zhao, Xingzhong Zhang et al.
Hyperhomocysteinemia (HHcy) is associated with an exaggerated platelet thrombotic response at sites of vascular injury. In this study, human medical examination showed that elevated human plasma Hcy levels correlated positively with enhanced blood coagulation and platelet activity, suggesting that h...
Golam Kabir, Mosaraf Hossain, M.O. Faruque, Naimul Hassan et al.
Aim and Background: Free IGF-1 and IGFBP-1 are associated with obesity which is one of the major features of insulin resistance. But very few studies exist on free IGF-1 and IGFBP-1 in IGT subjects. The present study was undertaken to investigate the association of free IGF-1 and IGFBP-1 with insuli...
Guofu Zhang, Qi Yang, Wenjian Mao, Yuepeng Hu et al.
Background GPIHBP1, a glycolipid-anchored protein of capillary endothelial cells, is a crucial partner for lipoprotein lipase (LPL) in plasma triglyceride metabolism. GPIHBP1 autoantibodies block LPL binding to GPIHBP1 and lead to severe hypertriglyceridemia (HTG) and HTG-induced acute pancreatitis ...
A B Kamrul-Hasan, Fatema Tuz Zahura Aalpona, Shahjada Selim
The clinical, metabolic and hormonal profiles of Bangladeshi adolescents with PCOS highlight risk factors and the need for clinical vigilance with respect to metabolic disease.
M J Uddin, Benyamin Alam, M.A. Jabbar, QD Mohammad et al.
This study is an observational case control study conducted in the Neurology department of Dhaka Medical college Hospital (DMCH) to see the relation of ischemic stroke with different components of serum lipids. Cases and controls were selected following certain inclusion and exclusion criteria. Resu...
Sharmin Akter
Non-alcoholic fatty liver disease (NAFLD) and its progressive subtype non-alcoholic steatohepatitis (NASH) are the most prevalent liver diseases, often leading to hepatocellular carcinoma (HCC). This review aims to describe the present knowledge of the risk factors responsible for the development of...
Hurjahan Banu, Md Shahed Morshed, Tania Sultana, Sukanti Shah et al.
Background: ). Aim: This study was aimed to see the magnitude of associations of VAI and LAP with cardiometabolic risk factors including IR and MetS in lean PCOS. Study Setting and Design: This cross-sectional study was done amongst 62 newly detected lean PCOS patients and 58 age- and BMI-matched he...
M. Jasimuddin Khan, W. Drochner, H. Steingaß, K.M.S. Islam
Potential nutritive value of 10 species of tree leaves (Streblus asper, Ficus infectoria, MOrLlS alba, Mang~fera indica, Erythrina indica, Albizia spp, Artocalpus integrifolia, Leucaena leucocephala, Zizyphus nzauritiarza and Sesbania sesban) of Bangladesh was studied. Chemical conlposition, fractio...