Alain Labrique, Khalequ Zaman, Mohammad Zahid Hossain, Pradip Kumar Saha et al.
Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis in the world. Most of South Asia is HEV endemic, with frequent seasonal epidemics of hepatitis E and continuous sporadic cases. This author group's epidemiologic work and clinical reports suggest that Bangladesh is HEV endemic...
Harshad Devarbhavi, Ashok Choudhury, Manoj Kumar Sharma, Rakhi Maiwall et al.
OBJECTIVES: Acute insults from viruses, infections, or alcohol are established causes of decompensation leading to acute-on-chronic liver failure (ACLF). Information regarding drugs as triggers of ACLF is lacking. We examined data regarding drugs producing ACLF and analyzed clinical features, labora...
Muhammad Torequl Islam, Cristina Quispe, Md. Amirul Islam, Eunüs S. Ali et al.
Nerol, a monoterpene is evident to possess diverse biological activities, including antioxidant, anti-microbial, anti-spasmodic, anthelmintic, and anti-arrhythmias. This study aims to evaluate its hepatoprotective effect against paracetamol-induced liver toxicity in a rat model. Five groups of rats ...
Lovkesh Anand, Ashok Choudhury, Chhagan Bihari, Barjesh Chander Sharma et al.
Autoimmune hepatitis (AIH) is considered less common in the Asia Pacific region. Due to this, AIH flare as a cause of acute on chronic liver failure (ACLF) is often overlooked and treatment delayed. We aimed at the defining clinical and histopathological spectrum and role of steroid therapy in AIH-A...
Rhoda MacKenzie, Amanda Lee, A. Paisley, Paul Burns et al.
Background and objective Superficial venous surgery for CEAP 2 disease leads to an improvement in disease-specific quality of life (QoL) in the short term. However, which factors influence the magnitude of this improvement, how surgery affects QoL in patients with CEAP 4 to 6 disease, and whether th...
Alain Labrique, Khalequ Zaman, Mohammad Zahid Hossain, Parimalendu Saha et al.
Hepatitis E virus (HEV) causes a substantial burden of sporadic and epidemic disease worldwide. HEV infections result in serious morbidity and mortality, especially among pregnant women, and have significant economic costs. Few population-based studies have characterized the epidemiology of HEV. A r...
Giuseppina La Rosa, Michele Muscillo, Valentina Spuri Vennarucci, Anna Rosa Garbuglia et al.
Human hepatitis E virus (HEV) is considered an emerging pathogen in industrialized countries. The aim of the present study was to contribute to the body of knowledge available on the molecular epidemiology of acute hepatitis E in Italy. Three sets of HEV-specific primers targeting the ORF1 and ORF2 ...
Xiangyu Dai, Chao Chen, Junchao Xue, Tian Xiao et al.
In the liver microenvironment, interactions among diverse types of hepatic cells are involved in liver fibrosis. In fibrotic tissues, exosomes act as transporters in intercellular communication. Long non-coding RNAs (lncRNAs) are involved in the activation of hepatic stellate cells (HSCs), which are...
Israt Ara Hossain, Md Mijanur Rahman Shah, Mohammad Khalilur Rahman, Liaquat Ali
Aims Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver-related morbidity and is frequently associated with insulin resistance (HOMA-IR) syndrome. Recently serum gamma glutamyl transferase (GGT) has been considered as surrogate marker of NAFLD leading to oxidative stress and hepatoce...
Tao Chen, Zhongyuan Yang, Ashok Choudhury, Mamun Al Mahtab et al.
Background and aim Cirrhosis is a controversial determinant of mortality in HBV-related acute-on-chronic liver failure (HBV-ACLF). The present study aimed to explore the effects of cirrhosis and the associated risk factors, especially its complications, on the outcome of HBV-ACLF. Methods A prospect...
Shahinul Alam, Jahangir Kabir, Golam Mustafa, UtpalDas Gupta et al.
BACKGROUND/AIM: Telmisartan can attenuate two hit pathogenesis of non-alcoholic steatohepatitis (NASH). This study aimed to observe the effect of Telmisartan on non-alcoholic fatty liver disease (NAFLD) activity score (NAS) and fibrosis score in NASH patients. PATIENTS AND METHODS: A total of 50 NAS...
Aleemuzzaman Sheikh, Masahiko Sugitani, Noriko Kinukawa, Mitsuhiko Moriyama et al.
This is the first study comparing hepatitis E virus (HEV) infection in Bangladesh in fulminant hepatitis (FH) patients presumed to have a viral cause and in the apparently healthy population. Sera from 22 FH patients were analyzed for antibodies to hepatitis A virus (HAV), hepatitis B virus (HBV), h...
Francesco Vizzutti, Ciro Celsa, Vincenza Calvaruso, Marco Enea et al.
BACKGROUND AND AIMS: Implantation of a transjugular intrahepatic portosystemic shunt (TIPS) improves survival in patients with cirrhosis with refractory ascites and portal hypertensive bleeding. However, the indication for TIPS in older adult patients (greater than or equal to 70 years) is debated, ...
Ashok Choudhury, Anand V. Kulkarni, Vinod Arora, Arvinder Singh Soin et al.
Acute-on-chronic liver failure (ACLF) is a condition associated with high mortality in the absence of liver transplantation. There have been various definitions proposed worldwide. The first consensus report of the working party of the Asian Pacific Association for the Study of the Liver (APASL) set...
Mohit Kehar, Rulan S. Parekh, Jennifer Stunguris, Maria De Angelis et al.
Background Living donor liver transplantation (LDLT) is increasingly used to bridge the gap between the current supply and demand imbalance for deceased donor organs to provide lifesaving liver transplantation. Methods Outcomes of 135 children who underwent LDLT were compared with 158 recipients of ...